iPTMnet Report for O95786 (RIGI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95786 / RIGI_HUMAN
Protein Name Antiviral innate immune response receptor RIG-I
Gene Name Name: RIGI
Synonyms:DDX58;
Organism Homo sapiens (Human)

PRO ID PR:O95786
DAG View
PRO Name antiviral innate immune response receptor RIG-I (human)
Definition An antiviral innate immune response receptor RIG-I that is encoded in the genome of human.
Short Label hRIGI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95786 (RIGI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) neXtProt   PhosphoSitePlus   RLIMS-P 22114345, 34935440, 20406818
K18 Methylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K48 Ubiquitination UniProt 28469175
K59 Acetylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus   UniProt 28469175
K99 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K146 Methylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123, 24755855
C158 Methylation IEDB 31844290
K164 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123, 24755855
K169 Ubiquitination PhosphoSitePlus
T170 Phosphorylation P05771 (PRKCB) , P17252 (PRKCA) neXtProt   PhosphoSitePlus   RLIMS-P 20071582, 34935440, 22114345
K172 Acetylation PhosphoSitePlus
K172 Ubiquitination PRO   PhosphoSitePlus   UniProt 19484123, 24755855, 28469175
K177 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus   UniProt 26471729
K190 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S437 Phosphorylation IEDB 35494241
K455 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
C680 Methylation IEDB 31844290
K757 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
T770 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236
K779 Ubiquitination PhosphoSitePlus
T785 O-Glycosylation GlyGen 30379171, 29351928
K788 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
S854 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236
S855 Phosphorylation Q14164 (IKBKE) , P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 21068236, 26354181
K858 Acetylation PhosphoSitePlus   UniProt 19608861
K858 Ubiquitination PhosphoSitePlus
Y879 Phosphorylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K888 Sumoylation PhosphoSitePlus
K909 Acetylation PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047161 (hRIGI/Ubiq:1) ubK154,ubK164,ubK172 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95786 (RIGI) S8 Q7Z434 (MAVS) unknown eFIP 20406818
Phosphorylation O95786 (RIGI) S8 Q14258 (TRIM25) decreased_association eFIP 20406818
Phosphorylation O95786 (RIGI) T170 Q7Z434 (MAVS) unknown eFIP 20071582


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 G8 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K48 N48 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K96 T96 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc, tcga ]
Y473 C473 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K491 Q491 Biomuta [ cosmic ]
T674 A674 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K679 T679 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S764 F764 Biomuta DOID:4159 / skin cancer [ cosmic ]
K788 T788 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K798 N798 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K858 R858 Biomuta DOID:3571 / liver cancer [ cosmic ]
K915 N915 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]