iPTMnet Report for O95696 (BRD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95696 / BRD1_HUMAN
Protein Name Bromodomain-containing protein 1
Gene Name Name: BRD1
Synonyms:BRL;
Organism Homo sapiens (Human)

PRO ID PR:O95696
DAG View
PRO Name bromodomain-containing protein 1 (human)
Definition A bromodomain-containing protein 1 that is encoded in the genome of human.
Short Label hBRD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95696 (BRD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K23 Acetylation PhosphoSitePlus
S25 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T27 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336
S131 Phosphorylation PhosphoSitePlus
C245 Methylation IEDB 31844290
Y328 Phosphorylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K368 Acetylation PhosphoSitePlus   UniProt 19608861
K368 Ubiquitination PhosphoSitePlus
K407 Acetylation PhosphoSitePlus
K413 Acetylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
S422 O-Glycosylation GlyGen 30379171
S422 Phosphorylation PhosphoSitePlus
T423 O-Glycosylation GlyGen 30379171
T446 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K516 Acetylation PhosphoSitePlus   UniProt 19608861
K519 Acetylation PhosphoSitePlus   UniProt 19608861
K523 Acetylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K554 Acetylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K614 Acetylation PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus   UniProt 23186163
T804 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
T845 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
K877 Acetylation PhosphoSitePlus
T885 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
K903 Acetylation PhosphoSitePlus   UniProt 19608861
R906 Phosphorylation UniProt 21406692
K981 Acetylation PhosphoSitePlus
K995 Acetylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
T1051 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1052 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
S1055 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S882 Phosphorylation PhosphoSitePlus
T905 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
K1126 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 P17 Biomuta DOID:1324 / lung cancer [ cosmic ]
S25 C25 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T27 M27 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T30 M30 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T32 A32 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T110 M110 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S131 F131 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S415 N415 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S422 Y422 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S502 F502 Biomuta DOID:4159 / skin cancer [ cosmic ]
K754 R754 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S808 F808 Biomuta DOID:4159 / skin cancer [ cosmic ]
S814 P814 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S859 I859 Biomuta DOID:1324 / lung cancer [ cosmic ]
T885 K885 Biomuta DOID:3571 / liver cancer [ cosmic ]
T885 M885 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
R906 M906 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1016 K1016 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1016 M1016 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
T1051 I1051 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1052 R1052 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1055 I1055 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1055 R1055 Biomuta [ cosmic ]