iPTMnet Report for O95453 (PARN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95453 / PARN_HUMAN
Protein Name Poly(A)-specific ribonuclease PARN
Gene Name Name: PARN
Synonyms:DAN;
Organism Homo sapiens (Human)

PRO ID PR:O95453
DAG View
PRO Name poly(A)-specific ribonuclease PARN (human)
Definition A poly(A)-specific ribonuclease PARN that is encoded in the genome of human.
Short Label hPARN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95453 (PARN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 19690332
T166 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S167 Phosphorylation PhosphoSitePlus   UniProt 23186163
K168 Ubiquitination PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus   UniProt 19608861
K223 Ubiquitination PhosphoSitePlus
Y238 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus   UniProt 19608861
K499 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus   UniProt 23186163
K532 Ubiquitination PhosphoSitePlus
Y552 Phosphorylation PhosphoSitePlus
S557 Phosphorylation P49137 (MAPKAPK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 16964243, ...20932473, 18669648, 24275569, 31387300, 20068231
S562 Phosphorylation PhosphoSitePlus
K566 Acetylation PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
S570 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S572 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S583 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S587 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T589 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S619 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...27920218, 20068231
S623 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S625 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus   UniProt 20068231
T631 Phosphorylation PhosphoSitePlus   UniProt 20068231
T638 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S151 Phosphorylation HPRD 20068231
S160 Phosphorylation HPRD 20068231
S163 Phosphorylation HPRD 19413330, 19651622, 16964243, ...19664995
T166 Phosphorylation HPRD 18669648, 20068231
S557 Phosphorylation HPRD 16964243, 18767875, 20058876, ...18669648, 20068231, 18212344
S570 Phosphorylation HPRD 18669648, 17081983
S572 Phosphorylation HPRD 18669648, 17081983, 19664995
S583 Phosphorylation HPRD 18669648
S587 Phosphorylation HPRD 19413330, 18669648
T589 Phosphorylation HPRD 18669648, 19664995
S619 Phosphorylation HPRD 17322306, 18767875, 19413330, ...20068231, 19651622
S623 Phosphorylation HPRD 19413330
S628 Phosphorylation HPRD 19413330, 20068231
T631 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K82 N82 Biomuta DOID:363 / uterine cancer [ icgc ]
Y161 D161 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S167 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T172 M172 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T172 A172 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K198 N198 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K250 Q250 Biomuta DOID:3571 / liver cancer [ cosmic ]
S557 N557 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S587 F587 Biomuta DOID:4159 / skin cancer [ cosmic ]
S625 L625 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]