iPTMnet Report for O95336 (PGLS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95336 / 6PGL_HUMAN
Protein Name 6-phosphogluconolactonase
Gene Name Name: PGLS
Organism Homo sapiens (Human)

PRO ID PR:O95336
DAG View
PRO Name 6-phosphogluconolactonase (human)
Definition A 6-phosphogluconolactonase that is encoded in the genome of human.
Short Label hPGLS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95336 (PGLS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 25944712
S46 Phosphorylation HPRD   PhosphoSitePlus 20068231
S49 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569, 20068231
R81 Methylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K180 Acetylation PhosphoSitePlus   UniProt 19608861
T204 Phosphorylation PhosphoSitePlus
T233 O-Glycosylation GlyGen 23301498, 28510447, 34229054, ...32870666, 29351928
K235 Ubiquitination PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R81 L81 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K128 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T204 A204 Biomuta DOID:3571 / liver cancer [ cosmic ]