iPTMnet Report for O95238 (SPDEF)
Protein Information
UniProt AC / UniProt ID | O95238 / SPDEF_HUMAN |
Protein Name | SAM pointed domain-containing Ets transcription factor |
Gene Name | Name: SPDEF Synonyms:PDEF,PSE; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O95238 |
PRO Name | SAM pointed domain-containing Ets transcription factor (human) |
Definition | A SAM pointed domain-containing Ets transcription factor that is encoded in the genome of human. |
Short Label | hSPDEF |
Category | organism-gene |
O95238 (SPDEF) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T50 | Phosphorylation | score0 | RLIMS-P | 20550708 | ||
S238 | Phosphorylation | Q9UQ88 (CDK11A) | score3 | PhosphoSitePlus Signor | 26885618 | |
S242 | Phosphorylation | Q9UQ88 (CDK11A) | score3 | PhosphoSitePlus Signor | 26885618 | |
S243 | Phosphorylation | Q9UQ88 (CDK11A) | score3 | PhosphoSitePlus Signor | 26885618 | |
S264 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y265 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y329 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T50 | M50 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S243 | L243 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S264 | R264 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y265 | C265 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |