iPTMnet Report for O95155 (UBE4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O95155 / UBE4B_HUMAN
Protein Name Ubiquitin conjugation factor E4 B
Gene Name Name: UBE4B
Synonyms:HDNB1;
Organism Homo sapiens (Human)

PRO ID PR:O95155
DAG View
PRO Name ubiquitin conjugation factor E4 B (human)
Definition A ubiquitin conjugation factor E4 B that is encoded in the genome of human.
Short Label hUBE4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O95155 (UBE4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
R10 Methylation PhosphoSitePlus
T22 O-Glycosylation GlyGen 23301498, 35008409, 28510447, ...35254053
T22 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S23 Phosphorylation PhosphoSitePlus   UniProt 23186163
T26 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T27 Phosphorylation PhosphoSitePlus
T30 O-Glycosylation GlyGen 23301498, 35008409, 28510447, ...35254053
T30 Phosphorylation PhosphoSitePlus
S31 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
T61 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S84 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S86 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S88 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569, ...19690332
S90 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S92 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S101 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S103 Phosphorylation PhosphoSitePlus   UniProt 21406692
S105 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163
C113 S-Nitrosylation dbSNO 26338901
S116 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163
S141 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S224 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S238 Phosphorylation PhosphoSitePlus   UniProt 23186163
S307 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus   UniProt 23186163
S392 Phosphorylation phospho.ELM 17081983
K442 Ubiquitination PhosphoSitePlus
C534 Methylation IEDB 31844290
K542 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus
T705 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
Y710 Phosphorylation PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
S798 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K801 Sumoylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
S803 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 18669648, 20068231
T807 Phosphorylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
Y929 Phosphorylation PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K964 Ubiquitination PhosphoSitePlus
S969 Phosphorylation PhosphoSitePlus
K972 Ubiquitination PhosphoSitePlus
K989 Ubiquitination PhosphoSitePlus
Y1026 Phosphorylation PhosphoSitePlus
T1034 Phosphorylation PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
K1106 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
C1164 Methylation IEDB 31844290
K1169 Ubiquitination PhosphoSitePlus
K1180 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
K1196 Ubiquitination PhosphoSitePlus
K1203 Ubiquitination PhosphoSitePlus
K1205 Ubiquitination PhosphoSitePlus
K1210 Ubiquitination PhosphoSitePlus
K1217 Ubiquitination PhosphoSitePlus
S1249 Phosphorylation PhosphoSitePlus
S1256 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 20068231
T1267 Phosphorylation PhosphoSitePlus
T1274 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 16964243
T26 Phosphorylation HPRD 18669648
T27 Phosphorylation HPRD 16964243
S31 Phosphorylation HPRD 18691976, 18669648, 16964243, ...20068231
S83 Phosphorylation HPRD 19651622
S84 Phosphorylation HPRD 18669648
S86 Phosphorylation HPRD 17081983
S87 Phosphorylation HPRD 19413330, 17081983
S88 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 19651622, 18669648
S90 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20058876, 19664995
S92 Phosphorylation HPRD 17322306, 19413330
T95 Phosphorylation HPRD 19413330
S99 Phosphorylation HPRD 18669648
S101 Phosphorylation HPRD 19651622, 18669648, 20068231
S103 Phosphorylation HPRD 19651622, 19664995
S105 Phosphorylation HPRD 19413330, 18767875, 18669648, ...15302935, 19664995
S224 Phosphorylation HPRD 18669648
S238 Phosphorylation HPRD 17322306
S669 Phosphorylation HPRD 18767875, 18669648, 17081983, ...20068231
S674 Phosphorylation HPRD 18691976, 18767875, 19651622, ...17322306, 18669648, 20068231
Y800 Phosphorylation HPRD 20068231
Y897 Phosphorylation HPRD 18452278
S915 Phosphorylation HPRD 18452278
S1136 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R10 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S23 C23 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T27 S27 Biomuta DOID:1324 / lung cancer [ cosmic ]
S88 L88 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S90 P90 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S92 R92 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T95 M95 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S101 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S141 N141 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S154 Y154 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S154 C154 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S224 N224 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S669 R669 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:1781 / thyroid cancer [ icgc ]
K702 R702 Biomuta DOID:3571 / liver cancer [ cosmic ]
S798 R798 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S915 Y915 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ]
S969 F969 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
T1034 M1034 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1106 * Biomuta [ cosmic ]
S1136 F1136 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S1265 F1265 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1267 M1267 Biomuta DOID:363 / uterine cancer [ icgc ]
T1274 M1274 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]