iPTMnet Report for O95096 (NKX2-2)
Protein Information
UniProt AC / UniProt ID | O95096 / NKX22_HUMAN |
Protein Name | Homeobox protein Nkx-2.2 |
Gene Name | Name: NKX2-2 Synonyms:NKX2.2,NKX2B; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O95096 |
PRO Name | homeobox protein Nkx-2.2 (human) |
Definition | A homeobox protein Nkx-2.2 that is encoded in the genome of human. |
Short Label | hNKX2-2 |
Category | organism-gene |
O95096 (NKX2-2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T6 | Phosphorylation | score1 | PhosphoSitePlus | |||
T8 | Phosphorylation | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
S58 | Phosphorylation | score1 | PhosphoSitePlus | |||
K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y152 | Phosphorylation | score1 | PhosphoSitePlus | |||
S163 | Phosphorylation | score1 | PhosphoSitePlus | |||
S199 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T6 | R6 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T8 | M8 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ] | |
T8 | A8 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S11 | L11 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
S58 | R58 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S58 | N58 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |