iPTMnet Report for O94992 (HEXIM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O94992 / HEXI1_HUMAN
Protein Name Protein HEXIM1
Gene Name Name: HEXIM1
Synonyms:CLP1,EDG1,HIS1,MAQ1;
Organism Homo sapiens (Human)

PRO ID PR:O94992
DAG View
PRO Name protein HEXIM1 (human)
Definition A protein HEXIM1 that is encoded in the genome of human.
Short Label hHEXIM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O94992 (HEXIM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S97 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S98 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
R146 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S158 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P 22821562, 31183407
K165 Acetylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S233 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 19690332, ...20068231
T236 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...18452278
S237 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18452278, 19651622, 18669648, ...19690332, 20068231
S252 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18452278, 18669648, ...19690332, 20068231
S260 Phosphorylation HPRD   phospho.ELM 18669648
S268 Phosphorylation PhosphoSitePlus   RLIMS-P 25900325
T270 Phosphorylation PhosphoSitePlus   RLIMS-P 17937499, 25900325
Y271 Phosphorylation PhosphoSitePlus   RLIMS-P 25900325
R273 Methylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus   RLIMS-P 25900325
T276 Phosphorylation PhosphoSitePlus
S278 Phosphorylation RLIMS-P 17937499
S283 Phosphorylation HPRD   PhosphoSitePlus 20068231
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Methylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
R331 Methylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
R347 Methylation PhosphoSitePlus
S355 O-Glycosylation GlyGen 23301498, 34019948, 31373491
S355 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) S392 O94992 (HEXIM1) unknown eFIP 24202322


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S97 L97 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S97 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y168 C168 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S237 I237 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S237 G237 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S268 L268 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R273 W273 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T276 A276 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K289 T289 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]