iPTMnet Report O94811 TPPP

Protein Information

UniProt AC / UniProt ID	O94811 / TPPP_HUMAN
Protein Name	Tubulin polymerization-promoting protein
Gene Name	Name: TPPP Synonyms:TPPP1;
Organism	Homo sapiens (Human)

PRO ID	PR:O94811 DAG View
PRO Name	tubulin polymerization-promoting protein (human)
Definition	A tubulin polymerization-promoting protein that is encoded in the genome of human.
Short Label	hTPPP
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O94811 (TPPP) as Substrate

O94811

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
T14	Phosphorylation	P28482 (MAPK1) , Q00535 (CDK5)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	17693641, 23355470, 18669648, ...24275569, 15822905
S18	Phosphorylation	P28482 (MAPK1) , Q00535 (CDK5)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	17693641, 18669648, 15822905, ...23355470
S23	Phosphorylation		score1	PhosphoSitePlus
K24	Acetylation		score1	PhosphoSitePlus
S32	Phosphorylation	P17612 (PRKACA)	score4	HPRD phospho.ELM PhosphoSitePlus UniProt	17693641, 18220336, 18669648, ...23093407, 20166139, 20068231
S35	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648
S45	Phosphorylation		score4	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 20068231, 23355470
S49	Phosphorylation		score2	HPRD phospho.ELM	18669648
K78	Methylation		score1	PhosphoSitePlus
T92	Phosphorylation	P17612 (PRKACA)	score3	PhosphoSitePlus UniProt	17693641
T94	O-Glycosylation		score3	GlyGen	29485866, 28657654, 20563614
S107	Phosphorylation		score3	PhosphoSitePlus UniProt	23093407
S152	O-Glycosylation		score2	GlyGen PhosphoSitePlus	28657654
T155	O-Glycosylation		score4	GlyGen PhosphoSitePlus	29485866, 28657654, 20563614
S159	O-Glycosylation		score3	GlyGen	29485866, 28657654, 20563614
S159	Phosphorylation	P17612 (PRKACA)	score4	PhosphoSitePlus UniProt	17693641, 23093407, 24275569
S160	Phosphorylation	P28482 (MAPK1) , Q00535 (CDK5)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	17693641, 18669648, 19413330, ...23355470
T162	Phosphorylation		score1	PhosphoSitePlus
K185	Acetylation		score1	PhosphoSitePlus
K187	Acetylation		score1	PhosphoSitePlus
K189	Acetylation		score1	PhosphoSitePlus
Y201	Phosphorylation		score1	PhosphoSitePlus
S203	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
T14	K14	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S23	*	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S32	L32	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ]
S49	G49	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
K78	R78	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T94	S94	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S107	T107	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S107	F107	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
T155	M155	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S159	L159	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S203	F203	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O94811 (TPPP)

Protein Information

Interactive Sequence View

O94811 (TPPP) as Substrate

PTM sites affected in variants