iPTMnet Report O94804 STK10

Protein Information

UniProt AC / UniProt ID	O94804 / STK10_HUMAN
Protein Name	Serine/threonine-protein kinase 10
Gene Name	Name: STK10 Synonyms:LOK;
Organism	Homo sapiens (Human)

PRO ID	PR:O94804 DAG View
PRO Name	serine/threonine-protein kinase 10 (human)
Definition	A serine/threonine-protein kinase 10 that is encoded in the genome of human.
Short Label	hSTK10
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O94804 (STK10) as Substrate

O94804

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
R11	Methylation		score1	PhosphoSitePlus
S13	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 23186163, ...20068231
T14	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976, 20068231
S20	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
K56	Ubiquitination		score1	PhosphoSitePlus
K65	Ubiquitination		score1	PhosphoSitePlus
C88	Methylation		score1	IEDB	31844290
K151	Ubiquitination		score1	PhosphoSitePlus
K159	Ubiquitination		score1	PhosphoSitePlus
T166	Phosphorylation		score1	PhosphoSitePlus
S179	Phosphorylation		score1	PhosphoSitePlus
K181	Ubiquitination		score1	PhosphoSitePlus
K184	Ubiquitination		score1	PhosphoSitePlus
T185	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18691976, 18669648, 20068231
S191	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 19369195
T195	Phosphorylation		score1	PhosphoSitePlus
Y197	Phosphorylation		score1	PhosphoSitePlus
T208	Phosphorylation		score1	PhosphoSitePlus
T259	Phosphorylation		score1	PhosphoSitePlus
K262	Ubiquitination		score1	PhosphoSitePlus
K277	Ubiquitination		score1	PhosphoSitePlus
K301	Acetylation		score1	IEDB	34357683
K301	Ubiquitination		score1	PhosphoSitePlus
S361	Phosphorylation		score1	IEDB	32387766
S387	Phosphorylation		score0	HPRD	18691976
T390	Phosphorylation		score0	HPRD	20068231
T391	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18691976, 18669648
S392	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976, 20068231
S413	Phosphorylation		score1	PhosphoSitePlus
S417	Phosphorylation		score1	PhosphoSitePlus
S438	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19369195, 18491316, 18088087, ...16964243, 19413330, 18691976, 18767875, 19664994, 15302935, 19664995, 17192257, 18452278, 17322306, 19367720, 18669648, 20058876, 19651622, 20166139, 23186163, 20068231
S444	Phosphorylation		score1	PhosphoSitePlus
K446	Ubiquitination		score1	PhosphoSitePlus
S448	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	19651622, 18669648, 20068231
S450	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 23186163, 19664994, ...19651622, 18669648, 20068231
S454	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus UniProt	19413330, 19664994, 19651622, ...18669648, 20068231
S455	Phosphorylation	O94804 (STK10)	score2	HPRD phospho.ELM PhosphoSitePlus	19413330, 19664994, 17192257, ...19651622, 18669648, 20068231
T459	Phosphorylation		score1	PhosphoSitePlus
S469	Phosphorylation		score1	PhosphoSitePlus
S485	Phosphorylation		score2	PhosphoSitePlus UniProt	24275569
S495	Phosphorylation		score1	PhosphoSitePlus
S514	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	23186163, 20068231, 24275569
T530	Phosphorylation		score1	PhosphoSitePlus
S545	Phosphorylation		score1	PhosphoSitePlus
S549	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
K621	Ubiquitination		score1	PhosphoSitePlus
S679	Phosphorylation		score1	PhosphoSitePlus
T688	Phosphorylation		score1	PhosphoSitePlus
K690	Acetylation		score1	PhosphoSitePlus
K701	Ubiquitination		score1	PhosphoSitePlus
K759	Ubiquitination		score1	PhosphoSitePlus
K796	Ubiquitination		score1	PhosphoSitePlus
K823	Ubiquitination		score1	PhosphoSitePlus
S824	Phosphorylation		score1	PhosphoSitePlus
K841	Ubiquitination		score1	PhosphoSitePlus
S844	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
K849	Ubiquitination		score1	PhosphoSitePlus
C947	Methylation		score1	IEDB	31844290
S951	Phosphorylation		score2	HPRD PhosphoSitePlus	19413330, 18452278, 20058876, ...18691976
T952	Phosphorylation	P28482 (MAPK1)	score2	HPRD neXtProt phospho.ELM PhosphoSitePlus UniProt	19413330, 18691976, 22028470, ...20058876, 19664995, 18452278, 18669648, 24275569, 20068231
S954	Phosphorylation		score1	PhosphoSitePlus
Y962	Phosphorylation		score1	PhosphoSitePlus
S968	Phosphorylation		score1	PhosphoSitePlus

O94804 (STK10) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O94804 (STK10)	S455	score0	HPRD	19413330, 19664994, 17192257, ...19651622, 18669648, 20068231
P15311 (EZR)	T567	score2	PhosphoSitePlus	19255442
P26038 (MSN)	T558	score3	neXtProt PhosphoSitePlus Signor	19255442
P35241 (RDX)	T564	score2	PhosphoSitePlus	19255442
P53350 (PLK1)	T210	score2	PhosphoSitePlus	12207013

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
R11	C11	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K65	E65	Biomuta	DOID:2531 / hematologic cancer [ cosmic, icgc ]
K65	R65	Biomuta	DOID:3953 / adrenal gland cancer [ cosmic ]
K181	N181	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
T195	M195	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K277	E277	Biomuta	DOID:2998 / testicular cancer [ cosmic ]
S387	F387	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S485	L485	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S485	P485	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S514	C514	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K621	N621	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K701	N701	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K701	Q701	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S824	G824	Biomuta	DOID:363 / uterine cancer [ icgc ]
K841	E841	Biomuta	DOID:363 / uterine cancer [ icgc ]
C947	Y947	Biomuta	DOID:1324 / lung cancer [ cosmic ]
C947	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S954	I954	Biomuta	DOID:4159 / skin cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for O94804 (STK10)

Protein Information

Interactive Sequence View

O94804 (STK10) as Substrate

O94804 (STK10) as PTM Enzyme

PTM sites affected in variants