iPTMnet Report for O76003 (GLRX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O76003 / GLRX3_HUMAN
Protein Name Glutaredoxin-3
Gene Name Name: GLRX3
Synonyms:PICOT;ORFNames:HUSSY-22;
Organism Homo sapiens (Human)

PRO ID PR:O76003
DAG View
PRO Name glutaredoxin-3 (human)
Definition A glutaredoxin-3 that is encoded in the genome of human.
Short Label hGLRX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O76003 (GLRX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895, 25944712
S32 Phosphorylation PhosphoSitePlus
K67 Sumoylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus   UniProt 23186163
S118 Phosphorylation HPRD   PhosphoSitePlus 18767875
S120 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18767875, 23186163
S124 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
C146 Methylation IEDB 31844290
C146 S-Nitrosylation dbSNO 24105792
K151 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
C159 Methylation IEDB 31844290
K163 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 A32 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S32 F32 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K67 N67 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C159 R159 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S183 L183 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S196 C196 Biomuta DOID:1324 / lung cancer [ cosmic ]
K240 T240 Biomuta DOID:363 / uterine cancer [ icgc ]