iPTMnet Report for O75928 (PIAS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75928 / PIAS2_HUMAN
Protein Name E3 SUMO-protein ligase PIAS2
Gene Name Name: PIAS2
Synonyms:PIASX;
Organism Homo sapiens (Human)

PRO ID PR:O75928
DAG View
PRO Name E3 SUMO-protein ligase PIAS2 (human)
Definition An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of human.
Short Label hPIAS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75928 (PIAS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S113 Phosphorylation neXtProt   Signor 16713578
S113 Phosphorylation Q15759 (MAPK11) neXtProt   Signor 16713578
S113 Phosphorylation Q16539 (MAPK14) Signor 16713578
S116 Phosphorylation neXtProt   Signor 16713578
S116 Phosphorylation Q15759 (MAPK11) neXtProt   Signor 16713578
S116 Phosphorylation Q16539 (MAPK14) Signor 16713578
K127 Sumoylation PhosphoSitePlus
K162 Sumoylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
K350 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K380 Sumoylation PhosphoSitePlus
K430 Sumoylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K443 Sumoylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K452 Sumoylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
K464 Sumoylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus   UniProt 21406692
S477 Phosphorylation PhosphoSitePlus   UniProt 21406692
S478 Phosphorylation PhosphoSitePlus   UniProt 21406692
K489 Sumoylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S476 Phosphorylation HPRD 19651622
S477 Phosphorylation HPRD 19651622
S478 Phosphorylation HPRD 19651622
S499 Phosphorylation HPRD 19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S476 Phosphorylation HPRD 19651622
S477 Phosphorylation HPRD 19651622
S478 Phosphorylation HPRD 19651622
S499 Phosphorylation HPRD 19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T338 S338 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K435 E435 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S476 I476 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S478 F478 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S499 N499 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]