iPTMnet Report for O75928 (PIAS2)
Protein Information
UniProt AC / UniProt ID | O75928 / PIAS2_HUMAN |
Protein Name | E3 SUMO-protein ligase PIAS2 |
Gene Name | Name: PIAS2 Synonyms:PIASX; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75928 |
PRO Name | E3 SUMO-protein ligase PIAS2 (human) |
Definition | An E3 SUMO-protein ligase PIAS2 that is encoded in the genome of human. |
Short Label | hPIAS2 |
Category | organism-gene |
O75928 (PIAS2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S12 | Phosphorylation | score1 | PhosphoSitePlus | |||
S17 | Phosphorylation | score1 | PhosphoSitePlus | |||
K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
K46 | Ubiquitination | score1 | PhosphoSitePlus | |||
S50 | Phosphorylation | score1 | PhosphoSitePlus | |||
S113 | Phosphorylation | Q16539 (MAPK14) , Q15759 (MAPK11) | score3 | neXtProt Signor | 16713578 | |
S116 | Phosphorylation | Q15759 (MAPK11) , Q16539 (MAPK14) | score3 | neXtProt Signor | 16713578 | |
K127 | Sumoylation | score1 | PhosphoSitePlus | |||
K162 | Sumoylation | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
K249 | Sumoylation | score1 | PhosphoSitePlus | |||
K249 | Ubiquitination | score1 | PhosphoSitePlus | |||
S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
K326 | Sumoylation | score1 | PhosphoSitePlus | |||
K326 | Ubiquitination | score1 | PhosphoSitePlus | |||
T338 | Phosphorylation | score1 | PhosphoSitePlus | |||
S339 | Phosphorylation | score1 | PhosphoSitePlus | |||
K350 | Sumoylation | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
K380 | Sumoylation | score1 | PhosphoSitePlus | |||
K430 | Sumoylation | score1 | PhosphoSitePlus | |||
K430 | Ubiquitination | score1 | PhosphoSitePlus | |||
K435 | Ubiquitination | score1 | PhosphoSitePlus | |||
K443 | Sumoylation | score1 | PhosphoSitePlus | |||
K443 | Ubiquitination | score1 | PhosphoSitePlus | |||
K452 | Sumoylation | score1 | PhosphoSitePlus | |||
K452 | Ubiquitination | score1 | PhosphoSitePlus | |||
S455 | Phosphorylation | score1 | PhosphoSitePlus | |||
S460 | Phosphorylation | score1 | PhosphoSitePlus | |||
K464 | Sumoylation | score1 | PhosphoSitePlus | |||
K464 | Ubiquitination | score1 | PhosphoSitePlus | |||
S476 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S477 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S478 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
K489 | Sumoylation | score1 | PhosphoSitePlus | |||
S494 | Phosphorylation | score1 | PhosphoSitePlus | |||
S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
T501 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T338 | S338 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
K435 | E435 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S476 | I476 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S478 | F478 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S499 | N499 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] |