iPTMnet Report for O75891 (ALDH1L1)
Protein Information
UniProt AC / UniProt ID | O75891 / AL1L1_HUMAN |
Protein Name | Cytosolic 10-formyltetrahydrofolate dehydrogenase |
Gene Name | Name: ALDH1L1 Synonyms:FTHFD; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75891 |
PRO Name | cytosolic 10-formyltetrahydrofolate dehydrogenase (human) |
Definition | A 10-formyltetrahydrofolate dehydrogenase that is encoded in the genome of human. |
Short Label | hALDH1L1 |
Category | organism-gene |
O75891 (ALDH1L1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S9 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
K35 | Acetylation | score1 | PhosphoSitePlus | |||
S57 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y105 | Phosphorylation | score1 | PhosphoSitePlus | |||
R112 | Methylation | score1 | PhosphoSitePlus | |||
K187 | Methylation | score1 | PhosphoSitePlus | |||
Y200 | Phosphorylation | score1 | PhosphoSitePlus | |||
S354 | Phosphorylation | score1 | PhosphoSitePlus | |||
S405 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y408 | Phosphorylation | score1 | PhosphoSitePlus | |||
T613 | Phosphorylation | score1 | PhosphoSitePlus | |||
S629 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S631 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
K660 | Acetylation | score1 | PhosphoSitePlus | |||
C662 | Methylation | score1 | IEDB | 31844290 | ||
C662 | S-Nitrosylation | score0 | dbSNO | 24105792 | ||
K668 | Acetylation | score1 | PhosphoSitePlus | |||
C686 | Methylation | score1 | IEDB | 31844290 | ||
S825 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
Y848 | Phosphorylation | score1 | PhosphoSitePlus | |||
K876 | Acetylation | score1 | PhosphoSitePlus | |||
K882 | Acetylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S405 | R405 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S405 | I405 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
T613 | A613 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S629 | F629 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S631 | C631 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S631 | F631 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K876 | I876 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |