iPTMnet Report for O75781 (PALM)
Protein Information
UniProt AC / UniProt ID | O75781 / PALM_HUMAN |
Protein Name | Paralemmin-1 precursor |
Gene Name | Name: PALM Synonyms:KIAA0270; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75781 |
PRO Name | paralemmin-1 (human) |
Definition | A paralemmin that is encoded in the genome of human. |
Short Label | hPALM |
Category | organism-gene |
O75781 (PALM) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378, 22223895 | ||
T59 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
S116 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
S124 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
T141 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
T145 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231 | ||
S152 | Phosphorylation | score1 | PhosphoSitePlus | |||
T154 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S162 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S171 | Phosphorylation | score1 | PhosphoSitePlus | |||
S189 | Phosphorylation | score1 | PhosphoSitePlus | |||
S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
S249 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y305 | Phosphorylation | score1 | PhosphoSitePlus | |||
K377 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T59 | Phosphorylation | score0 | HPRD | 18669648 | ||
S116 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
S124 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S138 | Phosphorylation | score0 | HPRD | 17081983, 20068231 | ||
T141 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
T145 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S152 | Phosphorylation | score0 | HPRD | 20068231 | ||
T154 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S162 | Phosphorylation | score0 | HPRD | 18669648, 19664994 | ||
S346 | Phosphorylation | score0 | HPRD | 15345747 | ||
T367 | Phosphorylation | score0 | HPRD | 15345747 | ||
S369 | Phosphorylation | score0 | HPRD | 15345747 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T59 | Phosphorylation | score0 | HPRD | 18669648 | ||
S116 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
S124 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S138 | Phosphorylation | score0 | HPRD | 17081983, 20068231 | ||
T141 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
T145 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S152 | Phosphorylation | score0 | HPRD | 20068231 | ||
T154 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S162 | Phosphorylation | score0 | HPRD | 18669648, 19664994 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T59 | M59 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] | |
T154 | M154 | Biomuta | [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S171 | T171 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S171 | L171 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |