iPTMnet Report for O75643 (SNRNP200)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75643 / U520_HUMAN
Protein Name U5 small nuclear ribonucleoprotein 200 kDa helicase
Gene Name Name: SNRNP200
Synonyms:ASCC3L1,BRR2;
Organism Homo sapiens (Human)

PRO ID PR:O75643
DAG View
PRO Name U5 small nuclear ribonucleoprotein 200 kDa helicase (human)
Definition A U5 small nuclear ribonucleoprotein 200 kDa helicase that is encoded in the genome of human.
Short Label hSNRNP200
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75643 (SNRNP200) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
S8 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
S8 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
K14 Methylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
R25 Methylation PhosphoSitePlus
S26 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T37 O-Glycosylation GlyGen 33465208
S42 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
S42 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation IEDB   PhosphoSitePlus 32897882
S225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 15302935, 18318008, 19367720, 18669648, 24275569, 20068231
S282 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
K284 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T295 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
C302 Methylation IEDB 31844290
K358 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus   UniProt 23186163
T393 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
R427 Methylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K469 Acetylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K479 Acetylation PhosphoSitePlus
K479 Methylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
C588 Methylation IEDB 31844290
T606 Phosphorylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K729 Acetylation PhosphoSitePlus
T731 Phosphorylation PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
T747 Phosphorylation PhosphoSitePlus
S756 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
K770 Ubiquitination PhosphoSitePlus
T795 Phosphorylation PhosphoSitePlus
K804 Methylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
Y922 Phosphorylation PhosphoSitePlus
Y924 Phosphorylation PhosphoSitePlus
Y926 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
K944 Acetylation PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K966 Ubiquitination PhosphoSitePlus
K971 Acetylation PhosphoSitePlus   UniProt 19608861
K971 Ubiquitination PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
T1028 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
K1039 Ubiquitination PhosphoSitePlus
K1049 Ubiquitination PhosphoSitePlus
S1056 Phosphorylation phospho.ELM 17081983
S1125 Phosphorylation PhosphoSitePlus
K1134 Ubiquitination PhosphoSitePlus
K1146 Ubiquitination PhosphoSitePlus
T1173 Phosphorylation PhosphoSitePlus
K1176 Acetylation PhosphoSitePlus
K1176 Ubiquitination PhosphoSitePlus
Y1177 Phosphorylation PhosphoSitePlus
Y1238 Phosphorylation PhosphoSitePlus
C1278 Methylation IEDB 31844290
K1294 Ubiquitination PhosphoSitePlus
Y1321 Phosphorylation PhosphoSitePlus
C1359 Methylation IEDB 31844290
K1396 Methylation IEDB 32357974
F1397 Methylation IEDB 32357974
K1404 Ubiquitination PhosphoSitePlus
T1409 Phosphorylation PhosphoSitePlus
K1417 Ubiquitination PhosphoSitePlus
K1421 Ubiquitination PhosphoSitePlus
T1428 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1431 Ubiquitination PhosphoSitePlus
K1443 Sumoylation PhosphoSitePlus
S1541 Phosphorylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
K1552 Ubiquitination PhosphoSitePlus
S1554 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...30379171, 34725712, 26853435, 29351928, 34019948, 35083852, 33465208, 32119511, 35289036, 22121020, 34229054
K1557 Ubiquitination PhosphoSitePlus
T1572 Phosphorylation PhosphoSitePlus
K1595 Acetylation PhosphoSitePlus
K1595 Ubiquitination PhosphoSitePlus
K1603 Ubiquitination PhosphoSitePlus
S1625 Phosphorylation PhosphoSitePlus
R1648 Methylation PhosphoSitePlus
Y1679 Phosphorylation PhosphoSitePlus
Y1682 Phosphorylation PhosphoSitePlus
C1731 Methylation IEDB 31844290
K1748 Ubiquitination PhosphoSitePlus
Y1754 Phosphorylation PhosphoSitePlus
Y1770 Phosphorylation PhosphoSitePlus
S1794 Phosphorylation PhosphoSitePlus
C1801 Methylation IEDB 31844290
Y1855 Phosphorylation PhosphoSitePlus
K1874 Ubiquitination PhosphoSitePlus
K1878 Ubiquitination PhosphoSitePlus
K1883 Ubiquitination PhosphoSitePlus
T1891 Phosphorylation PhosphoSitePlus
S1900 Phosphorylation PhosphoSitePlus
S1910 Phosphorylation PhosphoSitePlus
S1931 Phosphorylation PhosphoSitePlus
S1937 Phosphorylation PhosphoSitePlus
S1955 Phosphorylation PhosphoSitePlus
S1958 Phosphorylation PhosphoSitePlus
Y1959 Phosphorylation PhosphoSitePlus
K1961 Ubiquitination PhosphoSitePlus
K1972 Ubiquitination PhosphoSitePlus
S2002 Phosphorylation PhosphoSitePlus   UniProt 23186163
C2011 Methylation IEDB 31844290
S2020 Phosphorylation PhosphoSitePlus
Y2021 Phosphorylation PhosphoSitePlus
K2059 Ubiquitination PhosphoSitePlus
K2080 Ubiquitination PhosphoSitePlus
K2087 Ubiquitination PhosphoSitePlus
C2116 Methylation IEDB 31844290
T2131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S2133 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S2135 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation HPRD 18669648, 20068231
S207 Phosphorylation HPRD 20068231
S225 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 19007248, 18452278, 17322306, 18669648, 19651622, 18707149, 20166139, 19415658, 20068231, 19691289
Y540 Phosphorylation HPRD 20068231
S756 Phosphorylation HPRD 15302935
S1056 Phosphorylation HPRD 17081983
S2002 Phosphorylation HPRD 20058876
T2131 Phosphorylation HPRD 18669648
S2133 Phosphorylation HPRD 18669648
S2135 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y11 H11 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S17 L17 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
R25 H25 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T37 I37 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y102 C102 Biomuta DOID:1319 / brain cancer [ icgc ]
Y102 H102 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S225 F225 Biomuta DOID:4159 / skin cancer [ cosmic ]
T295 M295 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K426 I426 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R427 H427 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K469 * Biomuta DOID:363 / uterine cancer [ cosmic ]
K487 N487 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K557 E557 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K729 N729 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S932 T932 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1039 T1039 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1409 I1409 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1541 Y1541 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1544 N1544 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1625 G1625 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1648 W1648 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1648 L1648 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1748 R1748 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1878 T1878 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1910 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
C2011 S2011 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K2080 R2080 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]