iPTMnet Report for O75608 (LYPLA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75608 / LYPA1_HUMAN
Protein Name Acyl-protein thioesterase 1
Gene Name Name: LYPLA1
Synonyms:APT1,LPL1;
Organism Homo sapiens (Human)

PRO ID PR:O75608
DAG View
PRO Name acyl-protein thioesterase 1 (human)
Definition An acyl-protein thioesterase 1 that is encoded in the genome of human.
Short Label hLYPLA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75608 (LYPLA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K97 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
C144 Methylation IEDB 31844290
K190 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus   RLIMS-P 29648538
S210 Phosphorylation PhosphoSitePlus   RLIMS-P 29648538
C211 S-Nitrosylation dbSNO 26338901
K224 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S210 L210 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]