iPTMnet Report for O75607 (NPM3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75607 / NPM3_HUMAN
Protein Name Nucleoplasmin-3
Gene Name Name: NPM3
Organism Homo sapiens (Human)

PRO ID PR:O75607
DAG View
PRO Name nucleoplasmin-3 (human)
Definition A nucleoplasmin-3 that is encoded in the genome of human.
Short Label hNPM3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75607 (NPM3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 25944712, 20068231
T5 Phosphorylation PhosphoSitePlus
S13 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S16 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
R19 Methylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus   UniProt 24129315
K53 Sumoylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
C105 Methylation IEDB 31844290
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
T141 Phosphorylation HPRD   phospho.ELM 18669648
S143 Phosphorylation HPRD   phospho.ELM 18669648
S147 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 18452278
S151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 18452278
S158 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 W27 Biomuta DOID:1612 / breast cancer [ cosmic ]
K53 N53 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T141 M141 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]