iPTMnet Report for O75473 (LGR5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75473 / LGR5_HUMAN
Protein Name Leucine-rich repeat-containing G-protein coupled receptor 5 precursor
Gene Name Name: LGR5
Synonyms:GPR49,GPR67;
Organism Homo sapiens (Human)

PRO ID PR:O75473
DAG View
PRO Name leucine-rich repeat-containing G-protein coupled receptor 5 (human)
Definition A leucine-rich repeat-containing G-protein coupled receptor 5 that is encoded in the genome of human.
Short Label hLGR5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75473 (LGR5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y114 Phosphorylation PhosphoSitePlus
N208 N-Glycosylation GlyGen   UniProt 23756651
Y387 Phosphorylation PhosphoSitePlus
T446 Phosphorylation IEDB 35494241
S590 Phosphorylation PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
S844 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S861 Phosphorylation PhosphoSitePlus
S864 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y387 H387 Biomuta DOID:4159 / skin cancer [ cosmic ]
S590 F590 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S590 Y590 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S721 R721 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S844 L844 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S844 P844 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S848 I848 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S848 N848 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S854 C854 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S861 Y861 Biomuta DOID:4606 / bile duct cancer [ cosmic ]