iPTMnet Report for O75420 (GIGYF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75420 / GGYF1_HUMAN
Protein Name GRB10-interacting GYF protein 1
Gene Name Name: GIGYF1
Synonyms:CDS2,PERQ1;ORFNames:PP3360;
Organism Homo sapiens (Human)

PRO ID PR:O75420
DAG View
PRO Name GRB10-interacting GYF protein 1 (human)
Definition A GRB10-interacting GYF protein 1 that is encoded in the genome of human.
Short Label hGIGYF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75420 (GIGYF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
S21 Phosphorylation HPRD   PhosphoSitePlus 19664995
S24 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664995, 20068231
S28 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K35 Methylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S148 Phosphorylation PhosphoSitePlus
S155 O-Glycosylation GlyGen 23301498, 31492838, 28657654
S155 Phosphorylation PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus   UniProt 23186163
S195 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus   UniProt 24275569
S237 Phosphorylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus   UniProt 23186163
S438 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S442 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus   UniProt 23186163
C583 Methylation IEDB 31844290
T595 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
S634 O-Glycosylation GlyGen 23301498, 31492838, 28657654
S636 Phosphorylation HPRD   PhosphoSitePlus 20058876
S638 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 20058876, ...18669648, 20068231
S755 Phosphorylation HPRD 20068231
S756 Phosphorylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
K846 Ubiquitination PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
K858 Methylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus   UniProt 23186163
S863 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
K887 Ubiquitination PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K1003 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 F28 Biomuta DOID:4159 / skin cancer [ cosmic ]
K35 T35 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S195 R195 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S228 C228 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S228 F228 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S272 G272 Biomuta DOID:1612 / breast cancer [ cosmic ]
S443 F443 Biomuta DOID:1324 / lung cancer [ cosmic ]
S538 L538 Biomuta DOID:4159 / skin cancer [ cosmic ]
S831 R831 Biomuta DOID:4159 / skin cancer [ cosmic ]
S874 L874 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S874 W874 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K887 T887 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1003 E1003 Biomuta [ cosmic ]