iPTMnet Report for O75410 (TACC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75410 / TACC1_HUMAN
Protein Name Transforming acidic coiled-coil-containing protein 1
Gene Name Name: TACC1
Synonyms:KIAA1103;
Organism Homo sapiens (Human)

PRO ID PR:O75410
DAG View
PRO Name transforming acidic coiled-coil-containing protein 1 (human)
Definition A transforming acidic coiled-coil-containing protein 1 that is encoded in the genome of human.
Short Label hTACC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75410 (TACC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 20068231
A2 Myristoylation UniProt 25807930
S4 Phosphorylation PhosphoSitePlus   UniProt 20068231
S10 Phosphorylation PhosphoSitePlus   UniProt 20068231
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
T48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S52 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S54 Phosphorylation phospho.ELM 17081983
S55 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S57 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T63 Phosphorylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
K75 Methylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus   UniProt 23186163
S153 Phosphorylation PhosphoSitePlus   UniProt 23186163
T168 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S228 Phosphorylation Q9UQB9 (AURKC) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21531210
K234 Acetylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus   UniProt 23186163
T257 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S276 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
K286 Ubiquitination PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
Y533 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
S591 Phosphorylation PhosphoSitePlus   UniProt 24275569
C597 Methylation IEDB 31844290
T616 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K640 Acetylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K647 Acetylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
K754 Acetylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
C794 Methylation IEDB 31844290
K800 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 19651622, 20068231
S10 Phosphorylation HPRD 19651622, 20068231
S44 Phosphorylation HPRD 17525332, 18077418
S50 Phosphorylation HPRD 17081983
S52 Phosphorylation HPRD 17081983
S54 Phosphorylation HPRD 17081983
S55 Phosphorylation HPRD 17081983
S57 Phosphorylation HPRD 17081983
T168 Phosphorylation HPRD 20058876
S179 Phosphorylation HPRD 20058876
S276 Phosphorylation HPRD 19651622, 18669648, 17081983
Y533 Phosphorylation HPRD 15592455
Y730 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K6 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S55 L55 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T63 A63 Biomuta DOID:4159 / skin cancer [ cosmic ]
S94 L94 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S94 A94 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S147 F147 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S228 C228 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K240 N240 Biomuta DOID:363 / uterine cancer [ icgc ]
Y264 C264 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y264 H264 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T275 R275 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S276 R276 Biomuta DOID:363 / uterine cancer [ icgc ]
S347 G347 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K640 T640 Biomuta DOID:363 / uterine cancer [ icgc ]
K756 E756 Biomuta DOID:363 / uterine cancer [ icgc ]
C794 F794 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]