iPTMnet Report for O75351 (VPS4B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75351 / VPS4B_HUMAN
Protein Name Vacuolar protein sorting-associated protein 4B
Gene Name Name: VPS4B
Synonyms:SKD1,VPS42;ORFNames:MIG1;
Organism Homo sapiens (Human)

PRO ID PR:O75351
DAG View
PRO Name vacuolar protein sorting-associated protein 4B (human)
Definition A vacuolar protein sorting-associated protein 4B that is encoded in the genome of human.
Short Label hVPS4B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75351 (VPS4B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
T4 Phosphorylation HPRD 20068231
S5 Phosphorylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S93 Phosphorylation HPRD   PhosphoSitePlus   UniProt 24275569, 20068231
S102 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18088087, ...17081983, 18318008, 19651622, 18669648, 24275569, 20166139, 23186163, 20068231
S108 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231, ...24275569
K143 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
T317 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
S320 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332
K332 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus   UniProt 24275569
K422 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 L5 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K53 E53 Biomuta DOID:4159 / skin cancer [ cosmic ]
K53 N53 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S93 N93 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S102 C102 Biomuta DOID:1324 / lung cancer [ cosmic ]
S108 Y108 Biomuta DOID:363 / uterine cancer [ icgc ]
K180 T180 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y182 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T317 N317 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S358 P358 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]