iPTMnet Report for O75223 (GGCT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75223 / GGCT_HUMAN
Protein Name Gamma-glutamylcyclotransferase
Gene Name Name: GGCT
Synonyms:C7orf24,CRF21;
Organism Homo sapiens (Human)

PRO ID PR:O75223
DAG View
PRO Name gamma-glutamylcyclotransferase (human)
Definition A gamma-glutamylcyclotransferase that is encoded in the genome of human.
Short Label hGGCT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75223 (GGCT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S56 F56 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S93 Y93 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K118 N118 Biomuta [ cosmic ]
S136 F136 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S136 Y136 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]