iPTMnet Report for O75170 (PPP6R2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75170 / PP6R2_HUMAN
Protein Name Serine/threonine-protein phosphatase 6 regulatory subunit 2
Gene Name Name: PPP6R2
Synonyms:KIAA0685,PP6R2,SAPS2;
Organism Homo sapiens (Human)

PRO ID PR:O75170
DAG View
PRO Name serine/threonine-protein phosphatase 6 regulatory subunit 2 (human)
Definition A serine/threonine-protein phosphatase 6 regulatory subunit 2 that is encoded in the genome of human.
Short Label hPPP6R2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75170 (PPP6R2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S289 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S291 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
K698 Acetylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus   UniProt 23186163
S830 Phosphorylation PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
T887 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...32938750, 34019948, 30620550, 35132862, 35254053, 28657654
T899 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...32938750, 34019948, 30620550, 35132862, 35254053, 28657654
T903 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...34019948, 30620550, 35132862, 35254053, 28657654
T904 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...34019948, 30620550, 35132862, 35254053, 28657654
S907 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...32938750, 34019948, 30620550, 35132862, 35254053, 28657654
S919 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...34019948, 30620550, 35132862, 35254053, 28657654
S920 O-Glycosylation GlyGen 33214551, 35138101, 29351928, ...34019948, 30620550, 35132862, 35254053, 28657654
Site PTM Type PTM Enzyme Score Source PMID
K671 Acetylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S289 Phosphorylation HPRD 20166139, 18691976, 18669648, ...19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K15 E15 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T274 I274 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T278 A278 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S771 F771 Biomuta DOID:4159 / skin cancer [ cosmic ]
T887 A887 Biomuta DOID:3571 / liver cancer [ cosmic ]
S907 I907 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]