Protein Information

Cytoscape View


UniProt AC / UniProt ID O75056 / SDC3_HUMAN
Protein Name Syndecan-3
Gene Name Name: SDC3
Synonyms:KIAA0468;
Organism Homo sapiens (Human)

PRO ID PR:O75056
DAG View
PRO Name syndecan-3 (human)
Definition A syndecan-3 that is encoded in the genome of human.
Short Label hSDC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75056 (SDC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S108 O-Glycosylation GlyGen   UniProt 12407114
T109 O-Glycosylation GlyGen   UniProt 12407114
T110 O-Glycosylation GlyGen   UniProt 12407114
T146 Phosphorylation PhosphoSitePlus
S160 O-Glycosylation GlyGen   UniProt 12407114
T161 O-Glycosylation GlyGen   UniProt 12407114
T162 O-Glycosylation GlyGen   UniProt 12407114
T169 O-Glycosylation GlyGen   UniProt 12407114
S170 O-Glycosylation GlyGen   UniProt 12407114
T171 O-Glycosylation GlyGen   UniProt 12407114
T217 O-Glycosylation GlyGen 25813380
T218 O-Glycosylation GlyGen 25813380
T221 O-Glycosylation GlyGen 25813380
T225 O-Glycosylation GlyGen 30459171
T234 Phosphorylation PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
S250 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T251 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T253 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T264 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T265 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T291 O-Glycosylation GlyGen 25813380
T293 O-Glycosylation GlyGen 25813380
T324 O-Glycosylation GlyGen 30459171
S344 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T349 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T349 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation P54760 (EPHB4) HPRD   phospho.ELM   UniProt 9388509
K414 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y419 Phosphorylation P54760 (EPHB4) HPRD   phospho.ELM   UniProt 9388509
S428 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation P54760 (EPHB4) HPRD   phospho.ELM   UniProt 9388509
K433 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y441 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 9388509


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T169 I169 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T221 K221 Biomuta DOID:1324 / lung cancer [ cosmic ]
T221 M221 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S250 N250 Biomuta DOID:1319 / brain cancer [ icgc ]
T293 S293 Biomuta DOID:3571 / liver cancer [ cosmic ]
S344 L344 Biomuta DOID:1612 / breast cancer [ cosmic ]
K414 N414 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K433 T433 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K436 R436 Biomuta DOID:1324 / lung cancer [ cosmic ]