iPTMnet Report for O60841 (EIF5B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60841 / IF2P_HUMAN
Protein Name Eukaryotic translation initiation factor 5B
Gene Name Name: EIF5B
Synonyms:IF2,KIAA0741;
Organism Homo sapiens (Human)

PRO ID PR:O60841
DAG View
PRO Name eukaryotic translation initiation factor 5B (human)
Definition A eukaryotic translation initiation factor 5B that is encoded in the genome of human.
Short Label hEIF5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60841 (EIF5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 O-Glycosylation GlyGen 33465208
S9 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S12 O-Glycosylation GlyGen 33465208
S12 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
T13 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 28510447, 33465208
T13 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
K33 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S66 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664994, ...19651622, 18669648, 20068231
K73 Ubiquitination PhosphoSitePlus
T78 Phosphorylation HPRD   PhosphoSitePlus 20068231
S93 Phosphorylation PhosphoSitePlus
S107 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18452278, 19651622, 18669648, 24275569, 18318008, 20068231
S113 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 18767875, 15302935, 18452278, 19651622, 17322306, 18669648, 19690332, 24275569, 20166139, 18318008, 19415658, 20068231
S121 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y134 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...20230923, 18452278, 18669648, 20166139, 19690332, 20068231
S135 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 16083285, ...18088087, 20230923, 16097034, 15302935, 18452278, 19651622, 18669648, 19415658, 24275569, 20166139, 23186163, 19690332, 20068231
S137 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 16083285, ...18088087, 20230923, 18767875, 16097034, 18452278, 19651622, 17322306, 18669648, 19690332, 24275569, 20166139, 23186163, 19415658, 20068231
S164 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 23186163, ...18212344, 18767875, 15302935, 18452278, 19651622, 18669648, 19690332, 24275569, 20166139, 18318008, 19415658, 20068231, 17081983
S171 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 17081983, 18452278
S178 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S182 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16083285, 18767875, 15302935, ...18452278, 19651622, 18669648, 19690332, 24275569, 19415658, 20068231
S183 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 16083285, 18767875, ...18452278, 19651622, 18669648, 19690332, 20068231
S186 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 18767875, ...15302935, 18452278, 19651622, 18669648, 19415658, 19690332, 20068231
S190 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 16083285, 18767875, ...15302935, 18452278, 19651622, 18669648, 24275569, 19415658, 20068231
S196 Phosphorylation PhosphoSitePlus
S214 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18707149, 18691976, 21406692, ...23186163, 18212344, 20230923, 18452278, 19367720, 24275569, 17487921, 19690332, 19413330, 18767875, 20058876, 19651622, 15345747, 18491316, 17081983, 19664994, 19664995, 18669648, 20166139, 19415658, 20068231, 17924679
S222 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18452278
K275 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S295 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 34725712, 34019948, 28510447, 33465208
S295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T301 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T303 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus
S438 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
Y446 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
T486 Phosphorylation HPRD   PhosphoSitePlus 20068231
T498 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20068231
S511 Phosphorylation HPRD   PhosphoSitePlus 18452278
T515 Phosphorylation HPRD 18452278
S547 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S557 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
S560 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S584 Phosphorylation HPRD   PhosphoSitePlus 20166139
S588 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231
S589 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231, ...18452278
S591 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 18669648, 20068231, ...19651622
Y593 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20166139
S595 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231
C720 Methylation IEDB 31844290
K745 Ubiquitination PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
T775 Phosphorylation PhosphoSitePlus
K784 Acetylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K923 Acetylation PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
K932 Ubiquitination PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K968 Acetylation PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
T1000 Phosphorylation PhosphoSitePlus
S1001 Phosphorylation PhosphoSitePlus
C1092 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K1093 Ubiquitination PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
Y1100 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
K1153 Ubiquitination PhosphoSitePlus
K1160 Acetylation PhosphoSitePlus
S1168 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...15302935, 19664994, 18669648, 20068231
K1170 Acetylation PhosphoSitePlus
K1170 Ubiquitination PhosphoSitePlus
S1184 Phosphorylation PhosphoSitePlus
K1185 Ubiquitination PhosphoSitePlus
K1214 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K33 N33 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S113 R113 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S121 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y134 H134 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S135 Y135 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S171 R171 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S178 L178 Biomuta DOID:4159 / skin cancer [ cosmic ]
S182 Y182 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S222 F222 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S295 F295 Biomuta DOID:4159 / skin cancer [ cosmic ]
S411 F411 Biomuta DOID:4159 / skin cancer [ cosmic ]
S435 L435 Biomuta DOID:1324 / lung cancer [ cosmic ]
S438 F438 Biomuta DOID:4159 / skin cancer [ cosmic ]
T486 I486 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T515 I515 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S547 N547 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S557 G557 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S584 R584 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S588 G588 Biomuta [ cosmic ]
S589 L589 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y593 C593 Biomuta DOID:3571 / liver cancer [ cosmic ]
S595 F595 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y762 H762 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1185 N1185 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]