iPTMnet Report for O60832 (DKC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O60832 / DKC1_HUMAN
Protein Name H/ACA ribonucleoprotein complex subunit DKC1
Gene Name Name: DKC1
Synonyms:NOLA4;
Organism Homo sapiens (Human)

PRO ID PR:O60832
DAG View
PRO Name H/ACA ribonucleoprotein complex subunit DKC1 (human)
Definition An H/ACA ribonucleoprotein complex catalytic subunit that is encoded in the genome of human.
Short Label hDKC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O60832 (DKC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K12 Acetylation PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...16565220, 18669648, 19690332, 20068231
K39 Acetylation PhosphoSitePlus
K39 Sumoylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K43 Sumoylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
C230 Methylation IEDB 31844290
K257 Ubiquitination PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
C358 Methylation IEDB 31844290
K379 Acetylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus   UniProt 23186163
K394 Sumoylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K413 Sumoylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
S451 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 17287340, ...17081983, 18669648, 23186163, 20068231
S453 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 17287340, 20068231
S455 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 18669648, ...17081983
T458 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
K467 Sumoylation PhosphoSitePlus
K472 Acetylation PhosphoSitePlus
K474 Acetylation PhosphoSitePlus
K475 Acetylation PhosphoSitePlus
K477 Acetylation PhosphoSitePlus
S485 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
S494 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 24275569, 19690332, 20068231, 17081983
T496 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T497 Phosphorylation PhosphoSitePlus
S513 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 15302935, 18669648, 20068231, 16964243
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 18691976, 16565220, 19651622, ...18669648, 18452278, 20068231, 17924679
S422 Phosphorylation HPRD 19007248, 19691289
S451 Phosphorylation HPRD 19413330, 17287340, 17081983, ...19007248, 18452278, 19651622, 18669648, 18707149, 20068231, 19691289
S453 Phosphorylation HPRD 19413330, 16083285, 17287340, ...19007248, 18452278, 19651622, 18669648, 18707149, 19415658, 20068231
S455 Phosphorylation HPRD 19413330, 16083285, 19007248, ...18452278, 19651622, 18669648, 18707149, 19415658, 20068231, 19691289
T458 Phosphorylation HPRD 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
S485 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S494 Phosphorylation HPRD 19413330, 18691976, 18491316, ...16964243, 18767875, 19664994, 19007248, 18452278, 17322306, 18669648, 19651622, 19664995, 18707149, 20166139, 19415658, 20068231, 19691289
T496 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19691289, 18452278, 18669648, 19415658, 20068231
T497 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19691289, 18452278, 19415658, 20068231
S513 Phosphorylation HPRD 19413330, 18491316, 18212344, ...15302935, 19007248, 18452278, 19651622, 18669648, 16565220, 19415658, 20068231, 19691289


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K14 N14 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K20 E20 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K80 N80 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ]
K257 E257 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
K379 N379 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K394 R394 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K394 T394 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K433 Q433 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K472 M472 Biomuta DOID:4159 / skin cancer [ cosmic ]
K475 R475 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T496 I496 Biomuta DOID:363 / uterine cancer [ icgc ]
S513 F513 Biomuta DOID:1319 / brain cancer [ icgc ]