iPTMnet Report for O60825 (PFKFB2)
Protein Information
UniProt AC / UniProt ID | O60825 / F262_HUMAN |
Protein Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 |
Gene Name | Name: PFKFB2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O60825 |
PRO Name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (human) |
Definition | A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 that is encoded in the genome of human. |
Short Label | hPFKFB2 |
Category | organism-gene |
O60825 (PFKFB2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S2 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
S13 | Phosphorylation | score1 | PhosphoSitePlus | |||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
S32 | Phosphorylation | score1 | PhosphoSitePlus | |||
S84 | Phosphorylation | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
S175 | Phosphorylation | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
K279 | Ubiquitination | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
K298 | Ubiquitination | score1 | PhosphoSitePlus | |||
K305 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y356 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y358 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y366 | Phosphorylation | score1 | PhosphoSitePlus | |||
C397 | Methylation | score1 | IEDB | 31844290 | ||
T458 | Phosphorylation | score1 | PhosphoSitePlus | |||
S466 | Phosphorylation | P23443 (RPS6KB1) , P31749 (AKT1) , P54646 (PRKAA2) , Q13131 (PRKAA1) , P17612 (PRKACA) , P51812 (RPS6KA3) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 11069105, 23186163, ... | |
T468 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 36402789, 18220336 | ||
S471 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
S471 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S472 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
S472 | Phosphorylation | score1 | PhosphoSitePlus | |||
T475 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
T475 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
Y482 | Phosphorylation | score1 | PhosphoSitePlus | |||
S483 | Phosphorylation | P31749 (AKT1) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 30819197, 23457334, 29221144, ... | |
S486 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 36402789 | ||
S493 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 20068231, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S29 | Phosphorylation | score0 | HPRD | 20068231 | ||
S32 | Phosphorylation | score0 | HPRD | 20068231 | ||
S466 | Phosphorylation | P31749 (AKT1) , P54646 (PRKAA2) , P17612 (PRKACA) , Q13131 (PRKAA1) | score2 | HPRD | 19413330, 18767875, 19651622, ... | |
T468 | Phosphorylation | score0 | HPRD | 18767875, 18669648, 20068231 | ||
S471 | Phosphorylation | score0 | HPRD | 18669648 | ||
T475 | Phosphorylation | P17252 (PRKCA) | score2 | HPRD | 18669648, 1322130 | |
S483 | Phosphorylation | P31749 (AKT1) | score2 | HPRD | 12853467, 19651622, 18669648, ... | |
S486 | Phosphorylation | score0 | HPRD | 18669648 | ||
S493 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S29 | Phosphorylation | score0 | HPRD | 20068231 | ||
S32 | Phosphorylation | score0 | HPRD | 20068231 | ||
S463 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S29 | * | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
S32 | C32 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S84 | Y84 | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] | |
K192 | N192 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K287 | T287 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y356 | H356 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y366 | H366 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
Y366 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
C397 | R397 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
T458 | P458 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S493 | N493 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |