iPTMnet Report for O60353 (FZD6)
Protein Information
| UniProt AC / UniProt ID | O60353 / FZD6_HUMAN |
| Protein Name | Frizzled-6 precursor |
| Gene Name | Name: FZD6 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O60353 |
| PRO Name | frizzled-6 (human) |
| Definition | A frizzled-6 that is encoded in the genome of human. |
| Short Label | hFZD6 |
| Category | organism-gene |
DAG ViewO60353 (FZD6) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Ubiquitination | score1 | PRO | ||||
| T5 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N38 | N-Glycosylation | score1 | GlyGen | 29671580 | ||
| K108 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T136 | O-Glycosylation | score1 | GlyGen | 30459171, 25813380 | ||
| T141 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| K148 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T150 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533, 25813380 | ||
| K166 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K191 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T213 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S496 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S519 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S526 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K532 | Methylation | score1 | PhosphoSitePlus | |||
| K532 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K545 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S606 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T607 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| C615 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
| S620 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S624 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S626 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S629 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K636 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S641 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S648 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30309985 | ||
| S653 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S656 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| T659 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| T661 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K681 | Ubiquitination | score1 | PhosphoSitePlus |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000047477 (hFZD6/SigPep-/UbiqLys+) | ub | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T150 | I150 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| S496 | T496 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T607 | I607 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S620 | L620 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] | |
| S620 | T620 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S626 | C626 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S629 | F629 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
