iPTMnet Report for O43865 (AHCYL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43865 / SAHH2_HUMAN
Protein Name S-adenosylhomocysteine hydrolase-like protein 1
Gene Name Name: AHCYL1
Synonyms:DCAL,IRBIT,XPVKONA;
Organism Homo sapiens (Human)

PRO ID PR:O43865
DAG View
PRO Name S-adenosylhomocysteine hydrolase-like protein 1 (human)
Definition An S-adenosylhomocysteine hydrolase-like protein 1 that is encoded in the genome of human.
Short Label hAHCYL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43865 (AHCYL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S2 Acetylation UniProt 21406692
S2 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y28 Phosphorylation phospho.ELM   PhosphoSitePlus 17016520
S29 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S68 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17635105, 19220705, 16793548, ...27995898, 27279487
S71 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 16793548, 27995898, 19220705
T72 Phosphorylation PhosphoSitePlus
S74 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P   UniProt 27995898, 19220705, 32357974
S77 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27995898, 19220705
S84 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S103 Phosphorylation IEDB 32387766
K108 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
R249 Methylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
C272 S-Nitrosylation dbSNO 24105792
K284 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
C346 Methylation IEDB 31844290
K359 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S400 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T402 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T407 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R418 Methylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
Y482 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
R529 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
Y28 Phosphorylation HPRD 17016520, 15951569, 19901323
S391 Phosphorylation HPRD 18669648
S400 Phosphorylation HPRD 18669648
T402 Phosphorylation HPRD 18669648
T407 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43865 (AHCYL1) S71 Q14573 (ITPR3) unknown eFIP 27995898


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R249 Q249 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K284 N284 Biomuta DOID:4159 / skin cancer [ cosmic ]
K359 N359 Biomuta DOID:3571 / liver cancer [ cosmic ]
S400 P400 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S400 A400 Biomuta DOID:363 / uterine cancer [ cosmic ]
K432 E432 Biomuta DOID:9256 / colorectal cancer [ cosmic ]