iPTMnet Report for O43399 (TPD52L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43399 / TPD54_HUMAN
Protein Name Tumor protein D54
Gene Name Name: TPD52L2
Organism Homo sapiens (Human)

PRO ID PR:O43399
DAG View
PRO Name tumor protein D54 (human)
Definition A tumor protein D54 that is encoded in the genome of human.
Short Label hTPD52L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43399 (TPD52L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 22223895, ...20068231
S3 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S12 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18669648, 20068231
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
T23 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T35 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
R50 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
K90 Methylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S96 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
S96 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
S103 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
S104 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
Y106 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T121 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
Y126 Phosphorylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
S134 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
S134 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S152 Phosphorylation PhosphoSitePlus
S161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T163 Phosphorylation PhosphoSitePlus   UniProt 23186163
K165 Acetylation PhosphoSitePlus
K165 Methylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19367720, 18669648, 24275569, 17287340, 19690332, 20068231
R170 Methylation PhosphoSitePlus
T173 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
S186 Phosphorylation PhosphoSitePlus
S191 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...30059200, 35254053, 35132862, 33465208, 31492838, 31373491, 29351928, 30620550, 28657654, 29237092
S191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S195 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K198 Ubiquitination PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18669648, 18491316
S12 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 19651622, 18669648, 20068231
S19 Phosphorylation HPRD 18669648, 20068231, 20230923
S21 Phosphorylation HPRD 17322306, 20230923, 20058876, ...19651622, 18669648, 19415658, 20068231
T23 Phosphorylation HPRD 19651622, 18669648, 20068231
T29 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S96 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18212344, 20068231
S149 Phosphorylation HPRD 18491316
S161 Phosphorylation HPRD 17287340, 20068231
T163 Phosphorylation HPRD 20068231
S166 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T173 Phosphorylation HPRD 17287340, 18212344
S195 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S94 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18669648, 18491316
S12 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 19651622, 18669648, 20068231
S19 Phosphorylation HPRD 18669648, 20068231, 20230923
S21 Phosphorylation HPRD 17322306, 20230923, 20058876, ...19651622, 18669648, 19415658, 20068231
T23 Phosphorylation HPRD 19651622, 18669648, 20068231
T29 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S94 Phosphorylation PhosphoSitePlus
S96 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S103 Phosphorylation HPRD 20068231
S104 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S129 Phosphorylation HPRD 18491316
S148 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S157 Phosphorylation HPRD   PhosphoSitePlus 18212344
S169 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T176 Phosphorylation HPRD 17287340, 18212344
S198 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18669648, 18491316
S12 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 19651622, 18669648, 20068231
S19 Phosphorylation HPRD 18669648, 20068231, 20230923
S21 Phosphorylation HPRD 17322306, 20230923, 20058876, ...19651622, 18669648, 19415658, 20068231
T23 Phosphorylation HPRD 19651622, 18669648, 20068231
T29 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S96 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S103 Phosphorylation HPRD 20068231
S104 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S129 Phosphorylation HPRD   PhosphoSitePlus 18491316
S146 Phosphorylation PhosphoSitePlus
S148 Phosphorylation HPRD   PhosphoSitePlus 18212344
S160 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T167 Phosphorylation HPRD 17287340, 18212344
S189 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18669648, 18491316
S12 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 19651622, 18669648, 20068231
S19 Phosphorylation HPRD 18669648, 20068231, 20230923
S21 Phosphorylation HPRD 17322306, 20230923, 20058876, ...19651622, 18669648, 19415658, 20068231
T23 Phosphorylation HPRD 19651622, 18669648, 20068231
T29 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S96 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18212344, 20068231
S149 Phosphorylation HPRD 18491316
S166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation HPRD   PhosphoSitePlus 18212344
S180 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T187 Phosphorylation HPRD 17287340, 18212344
S209 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18669648, 18491316
S12 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17081983, 19651622, 18669648, 20068231
S19 Phosphorylation HPRD 18669648, 20068231, 20230923
S21 Phosphorylation HPRD 17322306, 20230923, 20058876, ...19651622, 18669648, 19415658, 20068231
T23 Phosphorylation HPRD 19651622, 18669648, 20068231
T29 Phosphorylation HPRD 20068231
S84 Phosphorylation HPRD 20068231
S96 Phosphorylation HPRD 17322306, 19651622, 18669648, ...18212344, 20068231
S149 Phosphorylation HPRD 18491316
S168 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S177 Phosphorylation HPRD   PhosphoSitePlus 18212344
S189 Phosphorylation HPRD 18691976, 17287340, 17081983, ...19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T196 Phosphorylation HPRD 17287340, 18212344
S218 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 F19 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S84 F84 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T146 K146 Biomuta [ cosmic ]
T146 S146 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S152 N152 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S160 P160 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S160 L160 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T163 P163 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T163 I163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S166 L166 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S166 P166 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S169 P169 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S169 L169 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R170 L170 Biomuta DOID:1324 / lung cancer [ cosmic ]
S180 P180 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S180 L180 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S189 L189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S189 P189 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]