iPTMnet Report for O43293 (DAPK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43293 / DAPK3_HUMAN
Protein Name Death-associated protein kinase 3
Gene Name Name: DAPK3
Synonyms:ZIPK;
Organism Homo sapiens (Human)

PRO ID PR:O43293
DAG View
PRO Name death-associated protein kinase 3 (human)
Definition A death-associated protein kinase 3 that is encoded in the genome of human.
Short Label hDAPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43293 (DAPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K37 Methylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S50 Phosphorylation O43293 (DAPK3) neXtProt   PhosphoSitePlus   UniProt 18239682
T112 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
T180 Phosphorylation O43293 (DAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611134, 17158456
T225 Phosphorylation O43293 (DAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611134, 17158456
T265 Phosphorylation Q13464 (ROCK1) , O43293 (DAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17158456, 32306542, 18239682, ...27573465, 18515077, 15611134, 16325270
K276 Ubiquitination PhosphoSitePlus
T299 Phosphorylation P53355 (DAPK1) , O43293 (DAPK3) , Q13464 (ROCK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611134, 17158456, 20854903, ...15367680
K303 Ubiquitination PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
T306 Phosphorylation O43293 (DAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611134
K308 Ubiquitination PhosphoSitePlus
S309 Phosphorylation P53355 (DAPK1) neXtProt   PRO   PhosphoSitePlus   UniProt 15367680
S311 Phosphorylation P53355 (DAPK1) , O43293 (DAPK3) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611134, 17158456, 15367680
S312 Phosphorylation P53355 (DAPK1) neXtProt   PRO   PhosphoSitePlus   UniProt 23186163, 15367680
S318 Phosphorylation P53355 (DAPK1) neXtProt   PRO   UniProt 15367680
S326 Phosphorylation P53355 (DAPK1) neXtProt   PRO   UniProt 15367680
K327 Ubiquitination PhosphoSitePlus
C349 Methylation IEDB 31844290
K363 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
S414 Phosphorylation IEDB   PhosphoSitePlus 27920218
K425 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
R454 Methylation PhosphoSitePlus


O43293 (DAPK3) as PTM Enzyme



Substrate Site Score Source PMID
O14950 (MYL12B) T19 neXtProt   PhosphoSitePlus   Signor 12429016, 11781833, 10356987, ...1178183
O14950 (MYL12B) S20 neXtProt   PhosphoSitePlus   Signor 11781833, 10356987, 1178183
O43293 (DAPK3) S50 neXtProt   UniProt 18239682
O43293 (DAPK3) T180 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15611134
O43293 (DAPK3) T225 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15611134, 17158456
O43293 (DAPK3) T265 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15611134, 17158456
O43293 (DAPK3) T299 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15611134, 17158456, 15367680
O43293 (DAPK3) T306 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15611134
O43293 (DAPK3) S311 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15611134, 17158456, 15367680
P04637 (TP53) S20 PhosphoSitePlus   Signor 17339337
P24844 (MYL9) T19 phospho.ELM   Signor 15096528, 19851336
P24844 (MYL9) S20 phospho.ELM   Signor 10356987, 19851336
P38936 (CDKN1A) T145 HPRD   neXtProt   PhosphoSitePlus 15001356
P40429 (RPL13A) S77 phospho.ELM   PhosphoSitePlus   Signor 18995835, 22771119, 23071094
P40763 (STAT3) S727 neXtProt 16219639
P68431 (H3C12) T12 phospho.ELM 12560483
Q00987 (MDM2) S166 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15001356
Q00987 (MDM2) S186 PhosphoSitePlus 15001356
Q96A00 (PPP1R14A) S12 phospho.ELM   PhosphoSitePlus 11287002
Q96A00 (PPP1R14A) T38 PhosphoSitePlus 11287002
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037783 (hRPL13A/InitMet-/AcPhos:1) acA2,pS77 PR:000037784 (hDAPK3/Phos:1) PRO 12962325, 18995835


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037784 (hDAPK3/Phos:1) pS309,pS311,pS312,pS318,pS326 PRO 15367680


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T112 M112 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K141 Q141 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T180 I180 Biomuta DOID:4159 / skin cancer [ cosmic ]
T225 M225 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y305 H305 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y305 C305 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 L309 Biomuta DOID:363 / uterine cancer [ icgc ]
K327 M327 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
R454 C454 Biomuta DOID:9256 / colorectal cancer [ cosmic ]