iPTMnet Report for O43290 (SART1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43290 / SNUT1_HUMAN
Protein Name U4/U6.U5 tri-snRNP-associated protein 1
Gene Name Name: SART1
Organism Homo sapiens (Human)

PRO ID PR:O43290
DAG View
PRO Name U4/U6.U5 tri-snRNP-associated protein 1 (human)
Definition A U4/U6.U5 tri-snRNP-associated protein 1 that is encoded in the genome of human.
Short Label hSART1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43290 (SART1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K94 Sumoylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K188 Sumoylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus   UniProt 23186163
K329 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus   UniProt 23186163
R385 Methylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus
T392 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163
K400 Ubiquitination PhosphoSitePlus
T430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 19690332
S437 Phosphorylation PhosphoSitePlus
S448 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 19690332, 20068231
S463 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T466 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S521 Phosphorylation PhosphoSitePlus   UniProt 20068231
K524 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
T556 O-Glycosylation GlyGen 31373491
S591 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S596 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 17081983, 20068231
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S621 Phosphorylation PhosphoSitePlus   UniProt 24275569
S623 Phosphorylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
Y673 Phosphorylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
Y685 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
R692 Methylation PhosphoSitePlus
T695 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K699 Ubiquitination PhosphoSitePlus
K709 Sumoylation PhosphoSitePlus
Y712 Phosphorylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T721 Phosphorylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
K742 Sumoylation PhosphoSitePlus
K749 Ubiquitination PhosphoSitePlus
K757 Methylation PhosphoSitePlus
K758 Methylation PhosphoSitePlus
K758 Sumoylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus   UniProt 23186163
S762 Phosphorylation PhosphoSitePlus
T764 Phosphorylation PhosphoSitePlus   UniProt 19690332
T768 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
T781 O-Glycosylation GlyGen 31373491
T781 Phosphorylation PhosphoSitePlus
Y783 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
T123 Phosphorylation HPRD 18491316
T392 Phosphorylation HPRD 18669648, 15302935, 20068231
T430 Phosphorylation HPRD 17525332
S448 Phosphorylation HPRD 17081983, 19664995, 18452278, ...19651622, 18669648, 18707149, 20166139, 20068231, 18212344
S463 Phosphorylation HPRD 18669648, 17081983, 18452278
T466 Phosphorylation HPRD 18669648, 17081983
S474 Phosphorylation HPRD 18669648, 18452278
S486 Phosphorylation HPRD 18669648, 18452278
S521 Phosphorylation HPRD 20068231
S591 Phosphorylation HPRD 17081983, 20068231, 18452278
S596 Phosphorylation HPRD 17081983, 20068231, 18452278
S598 Phosphorylation HPRD 17081983, 20068231, 18452278
T695 Phosphorylation HPRD 17525332
T764 Phosphorylation HPRD 19413330
S789 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 T89 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S108 T108 Biomuta DOID:1324 / lung cancer [ cosmic ]
S108 F108 Biomuta DOID:3571 / liver cancer [ cosmic ]
S112 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S348 F348 Biomuta DOID:4159 / skin cancer [ cosmic ]
R385 W385 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R385 Q385 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T430 A430 Biomuta DOID:363 / uterine cancer [ icgc ]
S437 F437 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S437 Y437 Biomuta DOID:1319 / brain cancer [ icgc ]
S486 L486 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K524 M524 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T556 M556 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S591 L591 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S598 T598 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S623 F623 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R692 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R692 Q692 Biomuta DOID:363 / uterine cancer [ icgc ]
K699 E699 Biomuta DOID:363 / uterine cancer [ icgc ]
T721 I721 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S762 N762 Biomuta DOID:263 / kidney cancer [ cosmic ]
S762 R762 Biomuta DOID:3571 / liver cancer [ cosmic ]
T764 M764 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K775 N775 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]