iPTMnet Report for O43255 (SIAH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43255 / SIAH2_HUMAN
Protein Name E3 ubiquitin-protein ligase SIAH2
Gene Name Name: SIAH2
Organism Homo sapiens (Human)

PRO ID PR:O43255
DAG View
PRO Name E3 ubiquitin-protein ligase SIAH2 (human)
Definition An E3 ubiquitin-protein ligase SIAH2 that is encoded in the genome of human.
Short Label hSIAH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43255 (SIAH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 33536006
T7 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
S16 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 22878263
S16 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor 22878263
T26 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 22878263, 19043406
T26 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 26751770
T26 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor 22878263
T26 Phosphorylation Q9H2X6 (HIPK2) neXtProt 19043406
S28 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 17003045, 22878263, ...19043406
S28 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 26751770
S28 Phosphorylation Q16539 (MAPK14) neXtProt 17003045
S28 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor 22878263
S28 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus 19043406
S68 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 19043406, 22878263, 26751770
S68 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 26751770
S68 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor 22878263
S68 Phosphorylation Q9H2X6 (HIPK2) neXtProt 19043406
K107 Ubiquitination PhosphoSitePlus
T119 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 26751770, 22878263
T119 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 26751770
T119 Phosphorylation Q92630 (DYRK2) neXtProt   PhosphoSitePlus   Signor 22878263
S132 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T275 Phosphorylation RLIMS-P 33536006
T279 Phosphorylation PhosphoSitePlus   RLIMS-P 33536006
S282 Phosphorylation RLIMS-P 33536006


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 R2 Biomuta DOID:263 / kidney cancer [ cosmic ]
S28 F28 Biomuta [ cosmic ]
T254 N254 Biomuta DOID:3571 / liver cancer [ cosmic ]
T275 I275 Biomuta DOID:1319 / brain cancer [ cosmic ]
T279 M279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T279 A279 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S282 L282 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S282 * Biomuta DOID:3571 / liver cancer [ cosmic ]