iPTMnet Report for O43237 (DYNC1LI2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O43237 / DC1L2_HUMAN
Protein Name Cytoplasmic dynein 1 light intermediate chain 2
Gene Name Name: DYNC1LI2
Synonyms:DNCLI2,LIC2;
Organism Homo sapiens (Human)

PRO ID PR:O43237
DAG View
PRO Name cytoplasmic dynein 1 light intermediate chain 2 (human)
Definition A cytoplasmic dynein 1 light intermediate chain 2 that is encoded in the genome of human.
Short Label hDYNC1LI2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O43237 (DYNC1LI2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K55 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...17081983, 15302935, 18669648, 32467330, 20068231
S203 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
R386 Methylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S391 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
R393 Methylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
R397 Methylation PhosphoSitePlus   UniProt 24129315
S402 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S407 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T410 O-Glycosylation GlyGen 23301498, 29485866, 34019948, ...35132862
T410 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
T441 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S443 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S446 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...18669648, 20068231
S454 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S194 Phosphorylation HPRD 19413330, 18691976, 18767875, ...19664994, 18452278, 17322306, 18669648, 19651622, 19415658, 20068231
S203 Phosphorylation HPRD 20068231
Y284 Phosphorylation HPRD 20068231
S383 Phosphorylation HPRD 19651622, 18669648, 20068231
S389 Phosphorylation HPRD 18691976
S391 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S405 Phosphorylation HPRD 18691976
S406 Phosphorylation HPRD 17322306, 19664995, 20068231
S407 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231
T441 Phosphorylation HPRD 19413330, 18691976, 18669648, ...19651622, 20068231
S443 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S446 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19651622, 19664995, 17322306, 18669648, 20068231
S487 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 N55 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S194 F194 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S205 F205 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y284 C284 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K318 N318 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S383 F383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R393 M393 Biomuta DOID:363 / uterine cancer [ icgc ]
R397 W397 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K440 N440 Biomuta DOID:363 / uterine cancer [ icgc ]
T441 A441 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S454 R454 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S466 L466 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S466 * Biomuta DOID:1324 / lung cancer [ cosmic ]