iPTMnet Report for O43237 (DYNC1LI2)
Protein Information
UniProt AC / UniProt ID | O43237 / DC1L2_HUMAN |
Protein Name | Cytoplasmic dynein 1 light intermediate chain 2 |
Gene Name | Name: DYNC1LI2 Synonyms:DNCLI2,LIC2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O43237 |
PRO Name | cytoplasmic dynein 1 light intermediate chain 2 (human) |
Definition | A cytoplasmic dynein 1 light intermediate chain 2 that is encoded in the genome of human. |
Short Label | hDYNC1LI2 |
Category | organism-gene |
O43237 (DYNC1LI2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K55 | Methylation | score1 | PhosphoSitePlus | |||
K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y184 | Phosphorylation | score1 | PhosphoSitePlus | |||
S194 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18691976, 21406692, 23186163, ... | ||
S203 | Phosphorylation | score1 | PhosphoSitePlus | |||
S205 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y284 | Phosphorylation | score1 | PhosphoSitePlus | |||
T291 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y292 | Phosphorylation | score1 | PhosphoSitePlus | |||
T297 | Phosphorylation | score1 | PhosphoSitePlus | |||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
K331 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y336 | Phosphorylation | score1 | PhosphoSitePlus | |||
S368 | Phosphorylation | score1 | PhosphoSitePlus | |||
K372 | Ubiquitination | score1 | PhosphoSitePlus | |||
T376 | Phosphorylation | score1 | PhosphoSitePlus | |||
S381 | Phosphorylation | score1 | PhosphoSitePlus | |||
S383 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
R386 | Methylation | score1 | PhosphoSitePlus | |||
S389 | Phosphorylation | score1 | PhosphoSitePlus | |||
S391 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
R393 | Methylation | score1 | PhosphoSitePlus | |||
T394 | Phosphorylation | score1 | PhosphoSitePlus | |||
R397 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
S402 | Phosphorylation | score1 | PhosphoSitePlus | |||
S405 | Phosphorylation | score1 | PhosphoSitePlus | |||
S406 | Phosphorylation | score1 | PhosphoSitePlus | |||
S407 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T410 | O-Glycosylation | score1 | GlyGen | 23301498, 29485866, 34019948, ... | ||
T410 | Phosphorylation | score1 | PhosphoSitePlus | |||
S425 | Phosphorylation | score1 | PhosphoSitePlus | |||
K440 | Ubiquitination | score1 | PhosphoSitePlus | |||
T441 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
S443 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
S446 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 16964243, ... | ||
S454 | Phosphorylation | score1 | PhosphoSitePlus | |||
S459 | Phosphorylation | score1 | PhosphoSitePlus | |||
K462 | Ubiquitination | score1 | PhosphoSitePlus | |||
S466 | Phosphorylation | score1 | PhosphoSitePlus | |||
S486 | Phosphorylation | score1 | PhosphoSitePlus | |||
S487 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S194 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18767875, ... | ||
S203 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y284 | Phosphorylation | score0 | HPRD | 20068231 | ||
S383 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
S389 | Phosphorylation | score0 | HPRD | 18691976 | ||
S391 | Phosphorylation | score0 | HPRD | 19651622, 18691976, 18669648, ... | ||
S405 | Phosphorylation | score0 | HPRD | 18691976 | ||
S406 | Phosphorylation | score0 | HPRD | 17322306, 19664995, 20068231 | ||
S407 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 19415658, ... | ||
T441 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18669648, ... | ||
S443 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 18669648, ... | ||
S446 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 16964243, ... | ||
S487 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K55 | N55 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S194 | F194 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S205 | F205 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y284 | C284 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
K318 | N318 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S383 | F383 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
R393 | M393 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
R397 | W397 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K440 | N440 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T441 | A441 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S454 | R454 | Biomuta | DOID:3953 / adrenal gland cancer [ cosmic ] | |
S466 | L466 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S466 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] |