iPTMnet Report for O15550 (KDM6A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15550 / KDM6A_HUMAN
Protein Name Lysine-specific demethylase 6A
Gene Name Name: KDM6A
Synonyms:UTX;
Organism Homo sapiens (Human)

PRO ID PR:O15550
DAG View
PRO Name lysine-specific demethylase 6A (human)
Definition A lysine-specific demethylase 6A that is encoded in the genome of human.
Short Label hKDM6A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15550 (KDM6A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T181 O-Glycosylation GlyGen 30620550
K225 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
R621 Methylation PhosphoSitePlus
T622 O-Glycosylation GlyGen 34846842
T625 O-Glycosylation GlyGen 23301498, 34019948, 30059200, ...35254053, 35132862, 29237092
S626 O-Glycosylation GlyGen 23301498, 34019948, 30620550, ...35132862, 35254053, 29237092, 30059200
K719 Sumoylation PhosphoSitePlus
S731 O-Glycosylation GlyGen 23301498, 34019948, 30059200, ...35254053, 35132862, 29237092
S761 Phosphorylation PhosphoSitePlus
S769 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 18452278
K799 Acetylation PhosphoSitePlus
T811 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S818 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 15302935, 15345747
T827 Phosphorylation HPRD   PhosphoSitePlus 19413330
S829 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18452278, ...15345747, 19690332
S926 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
S1061 Phosphorylation PhosphoSitePlus
S1091 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1097 Ubiquitination PhosphoSitePlus
T1131 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
K1287 Ubiquitination PhosphoSitePlus
K1301 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T181 I181 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K225 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K382 I382 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T387 S387 Biomuta DOID:1324 / lung cancer [ cosmic ]
T387 I387 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T535 I535 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S539 C539 Biomuta DOID:1324 / lung cancer [ cosmic ]
S552 I552 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S552 N552 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
R621 C621 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
R621 H621 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K719 T719 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S769 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S817 F817 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S818 L818 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y928 C928 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1018 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1018 E1018 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1018 M1018 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K1053 I1053 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S1061 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, tcga ]
S1284 L1284 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1284 * Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K1287 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]