iPTMnet Report for O15541 (RNF113A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15541 / R113A_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF113A
Gene Name Name: RNF113A
Synonyms:RNF113,ZNF183;
Organism Homo sapiens (Human)

PRO ID PR:O15541
DAG View
PRO Name E3 ubiquitin-protein ligase RNF113A (human)
Definition An E3 ubiquitin-protein ligase RNF113A that is encoded in the genome of human.
Short Label hRNF113A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15541 (RNF113A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 20068231
S6 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...19651622, 20068231
S43 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S46 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
T52 Phosphorylation HPRD 17081983
Y80 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340, 19651622, ...18669648, 20068231
S84 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17081983, 18452278, ...19651622, 18669648, 19690332, 19415658, 20068231, 18212344
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...17081983, 18452278, 19651622, 18669648, 19415658, 20068231, 18212344
Y100 Phosphorylation HPRD 20068231
K107 Acetylation PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K151 Sumoylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
K161 Sumoylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K166 Sumoylation PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K180 Sumoylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K227 Sumoylation PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation HPRD   PhosphoSitePlus 20058876
S253 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18452278, 19651622, 18669648, 24275569, 20166139, 15345747, 19415658, 20068231
S268 Phosphorylation PhosphoSitePlus
C277 Methylation IEDB 31844290
K316 Sumoylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 F6 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T52 S52 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T124 I124 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y153 C153 Biomuta DOID:1324 / lung cancer [ cosmic ]
T168 M168 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S174 F174 Biomuta DOID:4159 / skin cancer [ cosmic ]
T192 A192 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S216 R216 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
S268 C268 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S268 T268 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C277 W277 Biomuta DOID:263 / kidney cancer [ cosmic ]
T323 S323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]