iPTMnet Report for O15527 (OGG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15527 / OGG1_HUMAN
Protein Name N-glycosylase/DNA lyase
Gene Name Name: OGG1
Synonyms:MMH,MUTM,OGH1;
Organism Homo sapiens (Human)

PRO ID PR:O15527
DAG View
PRO Name N-glycosylase/DNA lyase (human)
Definition An N-glycosylase/DNA lyase that is encoded in the genome of human.
Short Label hOGG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15527 (OGG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S115 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K338 Acetylation PhosphoSitePlus
K341 Acetylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K338 Acetylation PR:000007102 (EP300) PRO 16478987
K341 Acetylation PR:000007102 (EP300) PRO 16478987


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028600 (hOGG1/iso:1/Ac:1) acK338,acK341 PR:000007102 (EP300) PRO 16478987


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S115 F115 Biomuta DOID:4159 / skin cancer [ cosmic ]
S326 C326 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
K338 E338 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]