iPTMnet Report for O15516 (CLOCK)
Protein Information
UniProt AC / UniProt ID | O15516 / CLOCK_HUMAN |
Protein Name | Circadian locomoter output cycles protein kaput |
Gene Name | Name: CLOCK Synonyms:BHLHE8,KIAA0334; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15516 |
PRO Name | circadian locomoter output cycles protein kaput (human) |
Definition | A circadian locomoter output cycles protein kaput that is encoded in the genome of human. |
Short Label | hCLOCK |
Category | organism-gene |
O15516 (CLOCK) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Phosphorylation | score1 | PRO | ||||
C7 | Methylation | score1 | IEDB | 31844290 | ||
K31 | Acetylation | score1 | PhosphoSitePlus | |||
K41 | Acetylation | score1 | PhosphoSitePlus | |||
S59 | Phosphorylation | score1 | PhosphoSitePlus | |||
K67 | Sumoylation | score1 | PhosphoSitePlus | |||
K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
S177 | Phosphorylation | score1 | PhosphoSitePlus | |||
K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y331 | Phosphorylation | score1 | PhosphoSitePlus | |||
K402 | Ubiquitination | score1 | PhosphoSitePlus | |||
S403 | Phosphorylation | score1 | PhosphoSitePlus | |||
S406 | Phosphorylation | score1 | PhosphoSitePlus | |||
S408 | Phosphorylation | score1 | PhosphoSitePlus | |||
K418 | Ubiquitination | score1 | PhosphoSitePlus | |||
S427 | Phosphorylation | P49841 (GSK3B) | score3 | PhosphoSitePlus RLIMS-P | 19946213 | |
T429 | Phosphorylation | score1 | PhosphoSitePlus | |||
S431 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 19946213 | ||
S434 | Phosphorylation | score1 | PhosphoSitePlus | |||
S437 | Phosphorylation | score1 | PhosphoSitePlus | |||
T443 | Phosphorylation | score1 | PhosphoSitePlus | |||
S446 | Phosphorylation | score1 | PhosphoSitePlus | |||
T451 | Phosphorylation | Q00535 (CDK5) | score3 | PhosphoSitePlus RLIMS-P Signor UniProt | 24235147 | |
S460 | Phosphorylation | score1 | PhosphoSitePlus | |||
T461 | Phosphorylation | Q00535 (CDK5) | score3 | PhosphoSitePlus RLIMS-P Signor UniProt | 24235147 | |
R702 | Methylation | score1 | PhosphoSitePlus | |||
T711 | O-Glycosylation | score3 | GlyGen | 23395176, 34019948, 28657654, ... | ||
S836 | Phosphorylation | score1 | PhosphoSitePlus | |||
K842 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S59 | P59 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
S164 | L164 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K418 | Q418 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T429 | A429 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
S431 | A431 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S446 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S460 | N460 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
T711 | A711 | Biomuta | DOID:1793 / pancreatic cancer [ icgc ] |