iPTMnet Report for O15503 (INSIG1)
Protein Information
UniProt AC / UniProt ID | O15503 / INSI1_HUMAN |
Protein Name | Insulin-induced gene 1 protein |
Gene Name | Name: INSIG1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15503 |
PRO Name | insulin-induced gene 1 protein (human) |
Definition | An insulin-induced gene 1 protein that is encoded in the genome of human. |
Short Label | hINSIG1 |
Category | organism-gene |
O15503 (INSIG1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S16 | Phosphorylation | score1 | PhosphoSitePlus | |||
K33 | Ubiquitination | score1 | PhosphoSitePlus | |||
S43 | Phosphorylation | score1 | PhosphoSitePlus | |||
S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
S74 | Phosphorylation | score1 | PhosphoSitePlus | |||
S125 | Phosphorylation | score1 | PhosphoSitePlus | |||
C146 | Methylation | score1 | IEDB | 31844290 | ||
K156 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 16399501 | ||
K158 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 16399501 | ||
C167 | Methylation | score1 | IEDB | 31844290 | ||
S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
S190 | Phosphorylation | score1 | PhosphoSitePlus | |||
S207 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 32322062 | ||
S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
T216 | Phosphorylation | score1 | PhosphoSitePlus | |||
T222 | Phosphorylation | score1 | PhosphoSitePlus | |||
S238 | Phosphorylation | score1 | PhosphoSitePlus | |||
C250 | Methylation | score1 | IEDB | 31844290 | ||
K273 | Ubiquitination | score1 | PhosphoSitePlus | |||
S276 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S43 | P43 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
S178 | N178 | Biomuta | [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
T222 | M222 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] |