iPTMnet Report for O15455 (TLR3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15455 / TLR3_HUMAN
Protein Name Toll-like receptor 3 precursor
Gene Name Name: TLR3
Organism Homo sapiens (Human)

PRO ID PR:O15455
DAG View
PRO Name Toll-like receptor 3 (human)
Definition A Toll-like receptor 3 that is encoded in the genome of human.
Short Label hTLR3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15455 (TLR3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N52 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 19159218
N57 N-Glycosylation GlyGen   UniProt 19159218
N70 N-Glycosylation GlyGen   UniProt 22579623, 16043704
T72 Phosphorylation PhosphoSitePlus
N124 N-Glycosylation GlyGen   UniProt 22579623, 15961631
N196 N-Glycosylation GlyGen   UniProt 16043704
S205 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
N247 N-Glycosylation GlyGen   UniProt 22579623, 24190977
N252 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
N265 N-Glycosylation GlyGen   UniProt 22579623, 16043704
N275 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
N291 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
S350 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
N398 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
N413 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
N507 N-Glycosylation GlyGen   UniProt 22579623, 16043704, 15961631
N636 N-Glycosylation GlyGen   UniProt 16043704
T638 O-Glycosylation GlyGen 35289036
Y759 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 27226571, 29636491, 12509442, ...22810896, 29383749, 17178723, 24526685
K812 Ubiquitination UniProt 37158982
T818 Phosphorylation PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus   UniProt 32878999
Y858 Phosphorylation P00533 (EGFR) PhosphoSitePlus   UniProt 22810896, 17178723
Site PTM Type PTM Enzyme Score Source PMID
S205 Phosphorylation HPRD 18452278
S206 Phosphorylation HPRD 18452278
T818 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N247 S247 Biomuta DOID:363 / uterine cancer [ icgc ]
N413 S413 Biomuta DOID:4159 / skin cancer [ cosmic ]
K812 T812 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]