iPTMnet Report for O15389 (SIGLEC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15389 / SIGL5_HUMAN
Protein Name Sialic acid-binding Ig-like lectin 5 precursor
Gene Name Name: SIGLEC5
Synonyms:CD33L2,OBBP2;
Organism Homo sapiens (Human)

PRO ID PR:O15389
DAG View
PRO Name sialic acid-binding Ig-like lectin 5 (human)
Definition A sialic acid-binding Ig-like lectin 5 that is encoded in the genome of human.
Short Label hSIGLEC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15389 (SIGLEC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N100 N-Glycosylation GlyGen 23090970, 24190977
N210 N-Glycosylation GlyGen 24190977
N231 N-Glycosylation GlyGen 24190977
N375 N-Glycosylation GlyGen 24190977
T485 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
Y520 Phosphorylation PhosphoSitePlus
Y544 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T487 I487 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S490 Y490 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S490 F490 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y544 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y544 C544 Biomuta DOID:3571 / liver cancer [ cosmic ]
S545 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S545 L545 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]