iPTMnet Report for O15379 (HDAC3)
Protein Information
UniProt AC / UniProt ID | O15379 / HDAC3_HUMAN |
Protein Name | Histone deacetylase 3 |
Gene Name | Name: HDAC3 |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15379 |
PRO Name | histone deacetylase 3 (human) |
Definition | A histone deacetylase 3 that is encoded in the genome of human. |
Short Label | hHDAC3 |
Category | organism-gene |
O15379 (HDAC3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K3 | Ubiquitination | score1 | PhosphoSitePlus | |||
K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
K44 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
S74 | Phosphorylation | score1 | PhosphoSitePlus | |||
K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
C123 | Methylation | score1 | IEDB | 31844290 | ||
C145 | Methylation | score1 | IEDB | 31844290 | ||
C251 | Methylation | score1 | IEDB | 31844290 | ||
C306 | Methylation | score1 | IEDB | 31844290 | ||
Y325 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y328 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31430896 | ||
Y331 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 31430896 | ||
S374 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 35494241 | ||
Y404 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y414 | Phosphorylation | score1 | PhosphoSitePlus | |||
S424 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P+ RLIMS-P Signor UniProt | 23186163, 17081983, 15805470, ... | ||
S424 | Phosphorylation | P68400 (CSNK2A1) | score4 | PhosphoSitePlus Signor | 26663086, 15805470 | |
S424 | Phosphorylation | Q5S007 (LRRK2) | score2 | RLIMS-P+ | 27798112 | |
S424 | Phosphorylation | Q9BXM7 (PINK1) | score2 | RLIMS-P+ | 25305081 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049891 (hHDAC3/iso:1/Phos:1) | pS424 | PRO | 27798112 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O15379 (HDAC3) | S424 | P00558 (PGK1) | increased_association | eFIP | 26356530 |
Proteoform PPIs
Protein 1 | Relation | Protein 2 | Source | PMID | |
---|---|---|---|---|---|
PR:O60566 (hBUB1B) | Interaction | PR:O15379 (hHDAC3) | PRO | ||
PR:P29590-5 (hPML/iso:5) | Interaction | PR:O15379 (hHDAC3) | PRO | 11259576 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K3 | N3 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K44 | N44 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S74 | N74 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
C251 | R251 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S424 | N424 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] |