iPTMnet Report for O15355 (PPM1G)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15355 / PPM1G_HUMAN
Protein Name Protein phosphatase 1G
Gene Name Name: PPM1G
Synonyms:PPM1C;
Organism Homo sapiens (Human)

PRO ID PR:O15355
DAG View
PRO Name protein phosphatase 1G (human)
Definition A protein phosphatase 1G that is encoded in the genome of human.
Short Label hPPM1G
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15355 (PPM1G) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805, 25807930
Y4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
C13 S-Nitrosylation dbSNO 20140087, 22178444
R22 Methylation PhosphoSitePlus   UniProt 24129315
C45 Methylation IEDB 31844290
K80 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus   UniProt 23186163
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S183 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18077418, ...26324325
S195 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18077418, 18669648
T196 Phosphorylation PhosphoSitePlus
T199 Phosphorylation HPRD   PhosphoSitePlus 18077418
S201 Phosphorylation HPRD   PhosphoSitePlus 18077418
T207 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
T234 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 26853435, 34019948, 35132862, 35083852, 32119511
S240 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 26853435, 34019948, 35132862, 35083852, 32119511
C241 S-Nitrosylation dbSNO 26338901
S245 Phosphorylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S327 Phosphorylation HPRD 20068231
K339 Ubiquitination PhosphoSitePlus
C351 S-Nitrosylation dbSNO 26338901
K358 Ubiquitination PhosphoSitePlus
K367 Sumoylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K383 Acetylation PhosphoSitePlus   UniProt 19608861
K383 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K406 Methylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S517 Phosphorylation HPRD   PhosphoSitePlus 20068231
K519 Acetylation PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
S527 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 21406692, 17287340
T528 Phosphorylation PhosphoSitePlus
S537 Phosphorylation HPRD   PhosphoSitePlus 20068231
K539 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K104 R104 Biomuta DOID:3571 / liver cancer [ cosmic ]
S173 C173 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S195 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S201 P201 Biomuta DOID:184 / bone cancer [ cosmic ]
S240 F240 Biomuta DOID:1324 / lung cancer [ cosmic ]
S245 C245 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S260 N260 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S264 L264 Biomuta DOID:1324 / lung cancer [ cosmic ]
S327 R327 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S527 F527 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S537 N537 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
K539 N539 Biomuta DOID:10283 / prostate cancer [ cosmic ]