iPTMnet Report for O15297 (PPM1D)
Protein Information
UniProt AC / UniProt ID | O15297 / PPM1D_HUMAN |
Protein Name | Protein phosphatase 1D |
Gene Name | Name: PPM1D Synonyms:WIP1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15297 |
PRO Name | protein phosphatase 1D (human) |
Definition | A protein phosphatase 1D that is encoded in the genome of human. |
Short Label | hPPM1D |
Category | organism-gene |
O15297 (PPM1D) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S10 | Phosphorylation | score1 | PhosphoSitePlus | |||
K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
S40 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19690332 | ||
S46 | Phosphorylation | score1 | PhosphoSitePlus | |||
S54 | Phosphorylation | score1 | PhosphoSitePlus | |||
S85 | Phosphorylation | Q9H2X6 (HIPK2) | score4 | PhosphoSitePlus UniProt | 23871434, 23186163 | |
S89 | Phosphorylation | score1 | PhosphoSitePlus | |||
S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
K162 | Acetylation | score1 | PhosphoSitePlus | |||
K184 | Acetylation | score1 | PhosphoSitePlus | |||
K218 | Ubiquitination | score1 | PhosphoSitePlus | |||
K223 | Ubiquitination | score1 | PhosphoSitePlus | |||
S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
K238 | Ubiquitination | score1 | PhosphoSitePlus | |||
S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y308 | Phosphorylation | score1 | PhosphoSitePlus | |||
S432 | Phosphorylation | score1 | PhosphoSitePlus | |||
K469 | Ubiquitination | score1 | PhosphoSitePlus | |||
T517 | Phosphorylation | score1 | PhosphoSitePlus | |||
T529 | Phosphorylation | score1 | PhosphoSitePlus | |||
K535 | Methylation | score1 | PhosphoSitePlus | |||
T537 | O-Glycosylation | score1 | GlyGen | 30379171 | ||
S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
S565 | Phosphorylation | score1 | PhosphoSitePlus | |||
S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
K589 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S46 | P46 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S54 | * | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
S54 | L54 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K218 | E218 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S239 | Y239 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
Y308 | F308 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y308 | C308 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K469 | * | Biomuta | DOID:3119 / gastrointestinal system cancer [ cosmic ] | |
K535 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
T537 | A537 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S570 | P570 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |