iPTMnet Report for O15118 (NPC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15118 / NPC1_HUMAN
Protein Name NPC intracellular cholesterol transporter 1 precursor
Gene Name Name: NPC1
Organism Homo sapiens (Human)

PRO ID PR:O15118
DAG View
PRO Name NPC intracellular cholesterol transporter 1 (human)
Definition An NPC intracellular cholesterol transporter 1 that is encoded in the genome of human.
Short Label hNPC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15118 (NPC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
N70 N-Glycosylation GlyGen   UniProt 10821832
K84 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
N122 N-Glycosylation GlyGen   UniProt 10821832, 27238017, 24190977
N135 N-Glycosylation GlyGen   UniProt 27238017, 19159218, 24190977
N154 N-Glycosylation GlyGen 24190977
N158 N-Glycosylation GlyGen   UniProt 19563754, 27238017, 24190977
K171 Ubiquitination PhosphoSitePlus
N185 N-Glycosylation GlyGen   UniProt 10821832, 24190977, 27238017, ...29741879
N188 N-Glycosylation GlyGen 24190977
N222 N-Glycosylation GlyGen   UniProt 29741879, 19563754, 27238017
Y302 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
N452 N-Glycosylation GlyGen   UniProt 28784760
N459 N-Glycosylation GlyGen   UniProt 28784760
N478 N-Glycosylation GlyGen   UniProt 26846330, 28784760
N524 N-Glycosylation GlyGen   UniProt 26846330, 27238017, 19159218, ...28784760
N557 N-Glycosylation GlyGen   UniProt 26846330, 28784760
N572 N-Glycosylation GlyGen   UniProt 26846330, 27238017
K585 Ubiquitination PhosphoSitePlus
N593 N-Glycosylation GlyGen 24190977
N596 N-Glycosylation GlyGen 24190977
N598 N-Glycosylation GlyGen   UniProt 26846330, 27238017, 28784760, ...24190977
K822 Ubiquitination PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
K877 Acetylation PhosphoSitePlus
K903 Acetylation PhosphoSitePlus
N916 N-Glycosylation GlyGen   UniProt 28784760
N931 N-Glycosylation GlyGen   UniProt 28784760
N961 N-Glycosylation GlyGen   UniProt 28784760, 24190977
N968 N-Glycosylation GlyGen   UniProt 28784760, 24190977
K987 Ubiquitination PhosphoSitePlus
K1013 Acetylation PhosphoSitePlus
K1057 Acetylation PhosphoSitePlus
N1064 N-Glycosylation GlyGen   UniProt 27238017, 28784760, 24190977
N1072 N-Glycosylation GlyGen 24190977
K1180 Ubiquitination PhosphoSitePlus
K1217 Acetylation PhosphoSitePlus
T1270 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T1270 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N70 D70 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
N188 S188 Biomuta DOID:184 / bone cancer [ cosmic ]
N222 S222 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S826 Y826 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1217 I1217 Biomuta DOID:5041 / esophageal cancer [ cosmic ]