iPTMnet Report for O15085 (ARHGEF11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15085 / ARHGB_HUMAN
Protein Name Rho guanine nucleotide exchange factor 11
Gene Name Name: ARHGEF11
Synonyms:KIAA0380;
Organism Homo sapiens (Human)

PRO ID PR:O15085
DAG View
PRO Name Rho guanine nucleotide exchange factor 11 (human)
Definition A Rho guanine nucleotide exchange factor 11 that is encoded in the genome of human.
Short Label hARHGEF11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15085 (ARHGEF11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
S8 Phosphorylation IEDB   PhosphoSitePlus 32387766
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus   UniProt 23186163
S27 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163
S38 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S245 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S251 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
T254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S255 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S271 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 23186163
S589 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus   UniProt 23186163
S651 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
T656 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
S663 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
T668 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 19690332
T672 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S679 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
K925 Acetylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
T1063 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1168 Phosphorylation PhosphoSitePlus
T1292 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1300 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1331 O-Glycosylation GlyGen 29351928
S1411 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
S1452 Phosphorylation PhosphoSitePlus
S1457 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1458 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T1461 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1462 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1466 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1478 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1489 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1491 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C1500 S-Nitrosylation dbSNO 26338901
S1519 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 20068231
S245 Phosphorylation HPRD 18669648, 20068231
S251 Phosphorylation HPRD 18669648, 17081983, 20068231
T254 Phosphorylation HPRD 18669648, 17081983, 20068231
S255 Phosphorylation HPRD 18669648, 17081983
S635 Phosphorylation HPRD 20166139
S663 Phosphorylation HPRD 19413330, 19651622, 17081983, ...17924679
T668 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19664994, 19651622, 18669648, 17924679
T672 Phosphorylation HPRD 19413330, 18767875, 18669648, ...17924679
S1155 Phosphorylation HPRD 18669648, 17081983
S1295 Phosphorylation HPRD 18669648, 19664994
S1300 Phosphorylation HPRD 18669648
S1457 Phosphorylation HPRD 18669648, 20068231
S1458 Phosphorylation HPRD 18669648
T1461 Phosphorylation HPRD 18669648, 20068231
T1462 Phosphorylation HPRD 18669648, 20068231
S1466 Phosphorylation HPRD 18669648
T1475 Phosphorylation HPRD 18669648
S1480 Phosphorylation HPRD 18669648, 19664994, 20068231
S1489 Phosphorylation HPRD 18669648
S1491 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 20068231
S206 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S285 Phosphorylation HPRD 18669648, 20068231
S291 Phosphorylation HPRD 18669648, 17081983, 20068231
T294 Phosphorylation HPRD 18669648, 17081983, 20068231
S295 Phosphorylation HPRD 18669648, 17081983
S675 Phosphorylation HPRD 20166139
S703 Phosphorylation HPRD 19413330, 19651622, 17081983, ...17924679
T708 Phosphorylation HPRD 19413330, 17081983, 18767875, ...19664994, 19651622, 18669648, 17924679
T712 Phosphorylation HPRD 19413330, 18767875, 18669648, ...17924679
S1195 Phosphorylation HPRD 18669648, 17081983
S1335 Phosphorylation HPRD 18669648, 19664994
S1340 Phosphorylation HPRD 18669648
S1497 Phosphorylation HPRD 18669648, 20068231
S1498 Phosphorylation HPRD 18669648
T1501 Phosphorylation HPRD 18669648, 20068231
T1502 Phosphorylation HPRD 18669648, 20068231
S1506 Phosphorylation HPRD 18669648
T1515 Phosphorylation HPRD 18669648
S1520 Phosphorylation HPRD 18669648, 19664994, 20068231
S1529 Phosphorylation HPRD 18669648
S1531 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 R8 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S27 F27 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S29 F29 Biomuta DOID:4159 / skin cancer [ cosmic ]
S29 C29 Biomuta DOID:4159 / skin cancer [ cosmic ]
S35 L35 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S206 N206 Biomuta DOID:4159 / skin cancer [ cosmic ]
S216 F216 Biomuta DOID:4159 / skin cancer [ cosmic ]
S242 L242 Biomuta [ cosmic ]
S256 F256 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S271 L271 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S657 F657 Biomuta DOID:3571 / liver cancer [ cosmic ]
T668 A668 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S679 N679 Biomuta [ cosmic ]
T708 A708 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1064 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1135 Y1135 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1155 G1155 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1195 G1195 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1411 G1411 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1452 F1452 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1462 M1462 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1466 N1466 Biomuta DOID:263 / kidney cancer [ cosmic ]
T1502 M1502 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1506 N1506 Biomuta DOID:263 / kidney cancer [ cosmic ]