iPTMnet Report for O15055 (PER2)
Protein Information
UniProt AC / UniProt ID | O15055 / PER2_HUMAN |
Protein Name | Period circadian protein homolog 2 |
Gene Name | Name: PER2 Synonyms:KIAA0347; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O15055 |
PRO Name | period circadian protein homolog 2 (human) |
Definition | A period circadian protein homolog 2 that is encoded in the genome of human. |
Short Label | hPER2 |
Category | organism-gene |
O15055 (PER2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Phosphorylation | score1 | PRO | ||||
Ubiquitination | score1 | PRO | ||||
S53 | Phosphorylation | score0 | RLIMS-P | 19491384 | ||
S77 | Phosphorylation | score1 | PhosphoSitePlus | |||
K113 | Ubiquitination | score1 | PhosphoSitePlus | |||
C166 | Methylation | score1 | IEDB | 31844290 | ||
S259 | Phosphorylation | score1 | PhosphoSitePlus | |||
K384 | Ubiquitination | score1 | PhosphoSitePlus | |||
C449 | Methylation | score1 | IEDB | 31844290 | ||
K453 | Ubiquitination | score1 | PhosphoSitePlus | |||
S480 | Phosphorylation | score1 | PhosphoSitePlus | |||
K539 | Acetylation | score1 | PhosphoSitePlus | |||
K553 | Acetylation | score1 | PhosphoSitePlus | |||
S566 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S580 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S627 | Phosphorylation | score1 | PhosphoSitePlus | |||
T645 | Phosphorylation | score1 | PhosphoSitePlus | |||
T649 | Phosphorylation | score1 | PhosphoSitePlus | |||
T652 | Phosphorylation | score1 | PhosphoSitePlus | |||
S653 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S662 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S662 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 11232563, 17218255, 21324900, ... | ||
S662 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 21324900 | |
S662 | Phosphorylation | P49674 (CSNK1E) | score3 | PhosphoSitePlus | 11232563, 21324900 | |
S665 | Phosphorylation | score2 | PhosphoSitePlus | 21324900 | ||
S665 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 21324900 | |
S665 | Phosphorylation | P49674 (CSNK1E) | score2 | PhosphoSitePlus | 21324900 | |
S668 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S668 | Phosphorylation | score2 | PhosphoSitePlus | 21324900 | ||
S668 | Phosphorylation | P48730 (CSNK1D) | score2 | PhosphoSitePlus | 21324900 | |
S668 | Phosphorylation | P49674 (CSNK1E) | score2 | PhosphoSitePlus | 21324900 | |
S671 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S696 | Phosphorylation | score1 | PhosphoSitePlus | |||
S700 | Phosphorylation | score1 | PhosphoSitePlus | |||
T734 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
K744 | Ubiquitination | score1 | PhosphoSitePlus | |||
C758 | Methylation | score1 | IEDB | 31844290 | ||
S766 | Phosphorylation | score1 | PhosphoSitePlus | |||
T774 | Phosphorylation | score1 | PhosphoSitePlus | |||
T781 | Phosphorylation | score1 | PhosphoSitePlus | |||
S782 | Phosphorylation | score1 | PhosphoSitePlus | |||
S786 | Phosphorylation | score1 | PhosphoSitePlus | |||
S810 | Phosphorylation | score1 | PhosphoSitePlus | |||
T965 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
T968 | Phosphorylation | score1 | PhosphoSitePlus | |||
S977 | Phosphorylation | score1 | PhosphoSitePlus | |||
S983 | O-Glycosylation | score4 | GlyGen PhosphoSitePlus | 30379171, 23395175 | ||
S1105 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1108 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1109 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1180 | O-Glycosylation | score3 | GlyGen | 30379171, 23395175 | ||
K1184 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S662 | Phosphorylation | score2 | HPRD | 11232563, 9349507 | ||
S662 | Phosphorylation | P49674 (CSNK1E) | score2 | HPRD | 11232563, 9349507 | |
S665 | Phosphorylation | score1 | HPRD | 17218255 | ||
S665 | Phosphorylation | P49674 (CSNK1E) | score1 | HPRD | 17218255 | |
S668 | Phosphorylation | score1 | HPRD | 17218255 | ||
S668 | Phosphorylation | P49674 (CSNK1E) | score1 | HPRD | 17218255 | |
S671 | Phosphorylation | score1 | HPRD | 17218255 | ||
S671 | Phosphorylation | P49674 (CSNK1E) | score1 | HPRD | 17218255 | |
S674 | Phosphorylation | score1 | HPRD | 17218255 | ||
S674 | Phosphorylation | P49674 (CSNK1E) | score1 | HPRD | 17218255 | |
S977 | Phosphorylation | score1 | HPRD | 16097765 | ||
S977 | Phosphorylation | P48730 (CSNK1D) | score1 | HPRD | 16097765 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000048747 (hPER2/PhosSer+) | p | PRO | |||
PR:000048748 (hPER2/pSerUbiq+) | p | PRO | |||
PR:000048748 (hPER2/pSerUbiq+) | ub | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S53 | L53 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K113 | T113 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S259 | Y259 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K384 | N384 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
K553 | R553 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
S566 | G566 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
T645 | M645 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T649 | R649 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S653 | L653 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S665 | P665 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S665 | L665 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S700 | F700 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T968 | P968 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S1108 | F1108 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T1180 | M1180 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |