iPTMnet Report for O15054 (KDM6B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15054 / KDM6B_HUMAN
Protein Name Lysine-specific demethylase 6B
Gene Name Name: KDM6B
Synonyms:JMJD3,KIAA0346;
Organism Homo sapiens (Human)

PRO ID PR:O15054
DAG View
PRO Name lysine-specific demethylase 6B (human)
Definition A lysine-specific demethylase 6B that is encoded in the genome of human.
Short Label hKDM6B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15054 (KDM6B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S68 O-Glycosylation GlyGen 29351928
S72 O-Glycosylation GlyGen 29351928
K73 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus   UniProt 23186163
T380 Phosphorylation PhosphoSitePlus
S399 O-Glycosylation GlyGen 29351928
S400 Phosphorylation PhosphoSitePlus
S402 O-Glycosylation GlyGen 29351928
S406 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
K689 Acetylation PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
T835 O-Glycosylation GlyGen 29351928
T894 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
S1085 Phosphorylation PhosphoSitePlus
K1091 Ubiquitination PhosphoSitePlus
K1109 Sumoylation PhosphoSitePlus
K1115 Ubiquitination PhosphoSitePlus
K1154 Ubiquitination PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
K1338 Ubiquitination PhosphoSitePlus
K1341 Ubiquitination PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
T1524 Phosphorylation PhosphoSitePlus
S1528 Phosphorylation PhosphoSitePlus
K1534 Ubiquitination PhosphoSitePlus
Y1563 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S399 T399 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ]
K487 R487 Biomuta DOID:1324 / lung cancer [ icgc ]
S1025 I1025 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1085 R1085 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1524 M1524 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1528 G1528 Biomuta DOID:9256 / colorectal cancer [ cosmic ]