iPTMnet Report for O15027 (SEC16A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O15027 / SC16A_HUMAN
Protein Name Protein transport protein Sec16A
Gene Name Name: SEC16A
Synonyms:KIAA0310,SEC16,SEC16L;
Organism Homo sapiens (Human)

PRO ID PR:O15027
DAG View
PRO Name protein transport protein Sec16A (human)
Definition A protein transport protein Sec16A that is encoded in the genome of human.
Short Label hSEC16A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O15027 (SEC16A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
R229 Methylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus   UniProt 24275569
T301 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231, ...17924679
R318 Methylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus   UniProt 23186163
S342 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   UniProt 24275569
S561 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus   UniProt 18669648
T575 Phosphorylation PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
S587 O-Glycosylation GlyGen 31373491
S587 Phosphorylation PhosphoSitePlus   UniProt 23186163
S589 O-Glycosylation GlyGen 32938750
S589 Phosphorylation PhosphoSitePlus   UniProt 18669648
S592 Phosphorylation PhosphoSitePlus   UniProt 18669648
T593 Phosphorylation PhosphoSitePlus   UniProt 18669648
S595 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T600 O-Glycosylation GlyGen 31373491
T600 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
Y748 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
R782 Methylation PhosphoSitePlus
S836 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30397120, 32574038, 31637018, 34019948, 35254053, 35132862, 30620550, 31373491, 35289036, 29351928, 34229054, 29237092
S846 Phosphorylation PhosphoSitePlus
S891 O-Glycosylation GlyGen   IEDB 28314751
S941 O-Glycosylation GlyGen 28314751
S957 Phosphorylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
T962 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
Y991 Phosphorylation PhosphoSitePlus
T997 Phosphorylation PhosphoSitePlus
T1001 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 34019948, 30397120, 32574038, 31637018, 34846842, 32938750, 35254053, 35132862, 30620550, 31373491, 35289036, 29351928, 34229054, 29237092
Y1009 Phosphorylation PhosphoSitePlus
S1012 O-Glycosylation GlyGen 34846842
S1014 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1019 O-Glycosylation GlyGen 34846842
S1019 Phosphorylation PhosphoSitePlus
S1022 O-Glycosylation GlyGen 34846842
S1022 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
Y1041 Phosphorylation PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S1079 Phosphorylation PhosphoSitePlus
S1119 O-Glycosylation IEDB 28314751
S1174 Phosphorylation PhosphoSitePlus
Y1188 Phosphorylation PhosphoSitePlus
Y1192 Phosphorylation PhosphoSitePlus
S1193 Phosphorylation PhosphoSitePlus
Y1195 Phosphorylation PhosphoSitePlus
Y1199 Phosphorylation PhosphoSitePlus
Y1202 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1209 Phosphorylation PhosphoSitePlus
Y1213 Phosphorylation PhosphoSitePlus
R1214 Methylation PhosphoSitePlus
Y1215 Phosphorylation PhosphoSitePlus
R1220 Methylation PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1226 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1242 Phosphorylation PhosphoSitePlus
Y1243 Phosphorylation PhosphoSitePlus
S1244 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30397120, 32574038, 31637018, 34019948, 35254053, 35132862, 30620550, 31373491, 35289036, 29351928, 34229054, 29237092
S1244 Phosphorylation PhosphoSitePlus
S1245 O-Glycosylation GlyGen 31373491
S1250 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
Y1275 Phosphorylation PhosphoSitePlus
Y1277 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus
Y1291 Phosphorylation PhosphoSitePlus
Y1297 Phosphorylation PhosphoSitePlus
Y1300 Phosphorylation PhosphoSitePlus
S1305 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1313 Ubiquitination PhosphoSitePlus
Y1320 Phosphorylation PhosphoSitePlus
T1325 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1327 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1347 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1350 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1353 Phosphorylation PhosphoSitePlus
S1356 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231, ...24275569
S1359 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S1362 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1365 Phosphorylation PhosphoSitePlus
R1366 Methylation PhosphoSitePlus
S1368 Phosphorylation PhosphoSitePlus
S1369 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1371 Phosphorylation PhosphoSitePlus
S1372 Phosphorylation PhosphoSitePlus
S1374 Phosphorylation PhosphoSitePlus
S1377 Phosphorylation PhosphoSitePlus
Y1380 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
S1389 Phosphorylation PhosphoSitePlus
Y1390 Phosphorylation PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
Y1405 Phosphorylation PhosphoSitePlus
S1410 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
T1427 Phosphorylation PhosphoSitePlus
S1436 Phosphorylation PhosphoSitePlus
S1437 Phosphorylation PhosphoSitePlus
T1440 Phosphorylation PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus
S1446 Phosphorylation PhosphoSitePlus
K1462 Sumoylation PhosphoSitePlus
K1462 Ubiquitination PhosphoSitePlus
K1503 Ubiquitination PhosphoSitePlus
K1508 Ubiquitination PhosphoSitePlus
K1518 Ubiquitination PhosphoSitePlus
K1521 Ubiquitination PhosphoSitePlus
S1573 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1583 Phosphorylation PhosphoSitePlus
S1601 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1627 Phosphorylation PhosphoSitePlus
R1656 Methylation PhosphoSitePlus
R1660 Methylation PhosphoSitePlus
T1754 Phosphorylation PhosphoSitePlus
K1773 Ubiquitination PhosphoSitePlus
S1801 Phosphorylation PhosphoSitePlus
S1810 Phosphorylation PhosphoSitePlus
S1841 Phosphorylation PhosphoSitePlus
K1865 Ubiquitination PhosphoSitePlus
T1907 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1939 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1946 Phosphorylation PhosphoSitePlus
T1956 Phosphorylation PhosphoSitePlus
S1964 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163, 17081983, ...18691976, 18669648, 24275569, 17924679, 19690332, 20068231, 16964243
T1988 Phosphorylation PhosphoSitePlus
S2022 Phosphorylation PhosphoSitePlus   UniProt 18691976, 16964243, 18669648, ...19690332, 20068231
S2037 Phosphorylation PhosphoSitePlus
S2039 Phosphorylation PhosphoSitePlus
S2042 Phosphorylation PhosphoSitePlus   UniProt 19690332
T2054 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S2056 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2073 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T2076 Phosphorylation PhosphoSitePlus
S2081 O-Glycosylation GlyGen 31373491
S2081 Phosphorylation PhosphoSitePlus
S2083 O-Glycosylation GlyGen 31373491
S2083 Phosphorylation PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 19690332, 20068231
K2097 Acetylation PhosphoSitePlus
T2099 Phosphorylation PhosphoSitePlus
K2103 Acetylation PhosphoSitePlus
K2104 Acetylation PhosphoSitePlus
S2107 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Y2122 Phosphorylation PhosphoSitePlus
K2129 Ubiquitination PhosphoSitePlus
S2130 Phosphorylation PhosphoSitePlus
K2137 Ubiquitination PhosphoSitePlus
T2158 O-Glycosylation GlyGen   PhosphoSitePlus 31373491
S2159 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...28314751, 35138101, 30397120, 32574038, 31637018, 34019948, 32938750, 35254053, 35132862, 30620550, 31373491, 35289036, 29351928, 34229054, 29237092
Y2182 Phosphorylation PhosphoSitePlus
S2183 Phosphorylation PhosphoSitePlus
Y2193 Phosphorylation PhosphoSitePlus
T2231 Phosphorylation PhosphoSitePlus
S2271 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S2275 Phosphorylation PhosphoSitePlus
S2279 Phosphorylation PhosphoSitePlus
S2285 Phosphorylation PhosphoSitePlus
S2291 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2295 Phosphorylation PhosphoSitePlus
S2297 Phosphorylation PhosphoSitePlus
S2298 Phosphorylation PhosphoSitePlus
S2300 Phosphorylation PhosphoSitePlus
S2304 Phosphorylation PhosphoSitePlus
T2339 Phosphorylation PhosphoSitePlus
S2340 Phosphorylation PhosphoSitePlus
S2342 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 20068231
S74 Phosphorylation HPRD 20068231
S122 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
T129 Phosphorylation HPRD 20068231
T197 Phosphorylation HPRD 20068231
S201 Phosphorylation HPRD 20068231
S314 Phosphorylation HPRD 18691976, 17322306, 18669648, ...19415658, 20068231, 17924679
S529 Phosphorylation HPRD 20068231
S568 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231
S569 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19664995, 18452278, 18669648, 19691289
T575 Phosphorylation HPRD 19413330, 18669648
S587 Phosphorylation HPRD 18669648, 17081983, 20068231
S589 Phosphorylation HPRD 18669648, 17081983, 20068231
S592 Phosphorylation HPRD 19651622, 18669648, 20068231
T593 Phosphorylation HPRD 19651622, 18669648, 20068231
S595 Phosphorylation HPRD 19651622, 18669648, 20068231
T600 Phosphorylation HPRD 18669648, 17081983
T605 Phosphorylation HPRD 18669648, 17081983
S606 Phosphorylation HPRD 17081983
S609 Phosphorylation HPRD 17081983
S610 Phosphorylation HPRD 17081983
S957 Phosphorylation HPRD 18669648, 20068231
T962 Phosphorylation HPRD 18669648
S984 Phosphorylation HPRD 20068231
S1069 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20068231
T1325 Phosphorylation HPRD 20166139, 20068231
S1327 Phosphorylation HPRD 18669648, 18452278
S1347 Phosphorylation HPRD 19651622, 20068231
S1350 Phosphorylation HPRD 19651622, 20068231
S1353 Phosphorylation HPRD 19651622, 20068231
S1356 Phosphorylation HPRD 19651622, 20068231
S1359 Phosphorylation HPRD 19651622, 19691289, 20068231
S1362 Phosphorylation HPRD 19651622
S1365 Phosphorylation HPRD 20068231
S1369 Phosphorylation HPRD 20068231
Y1380 Phosphorylation HPRD 19901323
S1398 Phosphorylation HPRD 18669648
S1436 Phosphorylation HPRD 19651622, 18669648, 18452278
S1437 Phosphorylation HPRD 19651622, 18669648
T1440 Phosphorylation HPRD 18669648, 18452278
S1441 Phosphorylation HPRD 18669648, 18452278
T1550 Phosphorylation HPRD 20068231
S1964 Phosphorylation HPRD 19413330, 18691976, 18491316, ...16964243, 19664995, 18669648, 19415658, 20068231, 17924679
S2022 Phosphorylation HPRD 18691976, 18669648, 16964243, ...20068231
T2054 Phosphorylation HPRD 18691976, 16964243, 19664994, ...19691289, 18669648, 20068231
S2073 Phosphorylation HPRD 16964243, 20068231
T2076 Phosphorylation HPRD 18669648
S2081 Phosphorylation HPRD 20058876, 18212344, 20068231
S2083 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664994, 19664995, 19651622, 18669648, 20166139, 19415658, 20068231
S2285 Phosphorylation HPRD 17525332
S2291 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S187 I187 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S331 F331 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S342 R342 Biomuta DOID:3571 / liver cancer [ cosmic ]
S520 N520 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S529 N529 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S561 I561 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T575 K575 Biomuta DOID:1612 / breast cancer [ cosmic ]
S595 N595 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S609 N609 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y748 S748 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S836 I836 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S961 N961 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T997 A997 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T1001 I1001 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1030 C1030 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1079 L1079 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1202 C1202 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R1214 C1214 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1214 S1214 Biomuta DOID:3571 / liver cancer [ cosmic ]
R1220 Q1220 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1226 N1226 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1243 C1243 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S1261 F1261 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1261 P1261 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1305 C1305 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1320 N1320 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T1325 M1325 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1356 I1356 Biomuta DOID:363 / uterine cancer [ icgc ]
R1366 C1366 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1369 C1369 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1389 F1389 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1390 * Biomuta DOID:263 / kidney cancer [ cosmic ]
Y1405 H1405 Biomuta DOID:363 / uterine cancer [ icgc ]
S1413 N1413 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1441 F1441 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1446 L1446 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1573 L1573 Biomuta DOID:363 / uterine cancer [ icgc ]
T1583 M1583 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S1801 C1801 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1956 M1956 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2039 P2039 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2056 L2056 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2073 L2073 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2083 L2083 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2099 K2099 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K2103 N2103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y2182 C2182 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y2193 C2193 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2342 N2342 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]